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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-1-6
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pubmed:abstractText |
In this study, we investigated the effect of CRM197 treatment in human adrenocortical carcinoma (AC) implanted in nude mice. CRM197 is a non-toxic mutant of diphtheria toxin that binds heparin-binding epidermal growth factor-like growth factor (HB-EGF) which is implicated in the proliferative activity of several tumor cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9794
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
425-32
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pubmed:meshHeading |
pubmed-meshheading:19996587-Adrenal Cortex Neoplasms,
pubmed-meshheading:19996587-Adrenocortical Carcinoma,
pubmed-meshheading:19996587-Animals,
pubmed-meshheading:19996587-Antineoplastic Agents,
pubmed-meshheading:19996587-Apoptosis,
pubmed-meshheading:19996587-Bacterial Proteins,
pubmed-meshheading:19996587-Blotting, Western,
pubmed-meshheading:19996587-Cell Movement,
pubmed-meshheading:19996587-Drug Screening Assays, Antitumor,
pubmed-meshheading:19996587-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19996587-Humans,
pubmed-meshheading:19996587-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:19996587-Male,
pubmed-meshheading:19996587-Mice,
pubmed-meshheading:19996587-Mice, Nude,
pubmed-meshheading:19996587-Neoplasm Transplantation,
pubmed-meshheading:19996587-Neovascularization, Pathologic,
pubmed-meshheading:19996587-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of adrenocortical carcinoma by diphtheria toxin mutant CRM197.
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pubmed:affiliation |
Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy. daniele.martarelli @ unicam.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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