Source:http://linkedlifedata.com/resource/pubmed/id/19969321
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2010-2-15
|
| pubmed:databankReference | |
| pubmed:abstractText |
To expand our knowledge of the genomic diversity of human papillomaviruses (HPVs), we searched for new HPVs in squamous cell carcinomas of the skin (SCC) and seemingly HPV-negative, otherwise typically HPV-associated lesions. We describe the characterization of three novel HPV types. HPV109 was isolated from an SCC, HPV112 from a condyloma and HPV114 from a low-grade cervical lesion. Pairwise alignment of the L1 sequences classified HPV114 to genus alpha species 3, whereas HPV112 defined a new species in the genus gamma. HPV109 had uncertain classification because of a low and about equal similarity in the L1 gene (between 60% and 65%) to different genera. Type-specific real-time PCRs of cervical samples, a majority from women with low grade atypical cytology, (n=2856) and various cutaneous samples (n=538), found HPV114 in 1.7% (48/2856) of the genital samples, whereas both HPV109 and 112 were rare viruses found at high viral loads only in their index samples.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1096-0341
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2009 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
20
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| pubmed:volume |
397
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
331-6
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| pubmed:meshHeading |
pubmed-meshheading:19969321-Adult,
pubmed-meshheading:19969321-Capsid Proteins,
pubmed-meshheading:19969321-Carcinoma, Squamous Cell,
pubmed-meshheading:19969321-Cervix Uteri,
pubmed-meshheading:19969321-DNA, Viral,
pubmed-meshheading:19969321-Female,
pubmed-meshheading:19969321-Humans,
pubmed-meshheading:19969321-Male,
pubmed-meshheading:19969321-Middle Aged,
pubmed-meshheading:19969321-Molecular Sequence Data,
pubmed-meshheading:19969321-Mucous Membrane,
pubmed-meshheading:19969321-Oncogene Proteins, Viral,
pubmed-meshheading:19969321-Papillomaviridae,
pubmed-meshheading:19969321-Papillomavirus Infections,
pubmed-meshheading:19969321-Phylogeny,
pubmed-meshheading:19969321-Sequence Alignment,
pubmed-meshheading:19969321-Sequence Analysis, DNA,
pubmed-meshheading:19969321-Skin Diseases, Viral,
pubmed-meshheading:19969321-Skin Neoplasms,
pubmed-meshheading:19969321-Warts
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Three novel papillomaviruses (HPV109, HPV112 and HPV114) and their presence in cutaneous and mucosal samples.
|
| pubmed:affiliation |
Department of Laboratory Medicine, Lund University, Malmö University Hospital, Entrance 78, 205 02 Malmö, Sweden.
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| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|