Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-3-25
pubmed:abstractText
A series of mutation experiments was carried out with Drosophila melanogaster using inhalation exposure. 1,2-Dichloroethane (DCE) and 1,2-dibromoethane (DBE) were active in the sex-linked recessive lethal assay (SLRLT), whereas dichloromethane, dibromomethane, 1,2-dichloropropane and 1,3-dichloropropane were not. Compared to DBE, DCE is a less potent mutagen in the SLRL system. For both compounds, there is no evidence of a clear-cut dose-rate effect. DCE and dichloromethane were also investigated in the somatic mutation and recombination test (SMART), with results similar to those from the SLRLT. For DCE the genetic activity profile was further analyzed by carrying out a sex-chromosome loss assay and a complementation analysis of a series of induced recessive lethal mutations. A review of the use of inhalation in mutagenicity assays with Drosophila shows that this route of exposure is an effective one. Especially with chronic exposure times, rather low exposure concentrations can be detected. With compounds of intermediate volatility inhalation is not superior to other modes of administration; nor is it likely to be sensitive enough for in situ monitoring.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-33
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed-meshheading:1996129-Administration, Inhalation, pubmed-meshheading:1996129-Animals, pubmed-meshheading:1996129-Chromosome Mapping, pubmed-meshheading:1996129-Dose-Response Relationship, Drug, pubmed-meshheading:1996129-Drosophila, pubmed-meshheading:1996129-Ethylene Dibromide, pubmed-meshheading:1996129-Ethylene Dichlorides, pubmed-meshheading:1996129-Gene Frequency, pubmed-meshheading:1996129-Genes, Lethal, pubmed-meshheading:1996129-Glutathione, pubmed-meshheading:1996129-Hydrocarbons, Brominated, pubmed-meshheading:1996129-Hydrocarbons, Halogenated, pubmed-meshheading:1996129-Male, pubmed-meshheading:1996129-Methylene Chloride, pubmed-meshheading:1996129-Mutagenesis, pubmed-meshheading:1996129-Mutation, pubmed-meshheading:1996129-Propane, pubmed-meshheading:1996129-Recombination, Genetic, pubmed-meshheading:1996129-Ring Chromosomes
pubmed:year
1991
pubmed:articleTitle
Inhalation exposure in Drosophila mutagenesis assays: experiments with aliphatic halogenated hydrocarbons, with emphasis on the genetic activity profile of 1,2-dichloroethane.
pubmed:affiliation
National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
pubmed:publicationType
Journal Article