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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-5
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pubmed:abstractText |
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, are important drugs used in the treatment and prevention of cardiovascular disease. Although statins are well tolerated, many patients develop myopathy manifesting as muscle aches and pain. Rhabdomyolysis is a rare but severe toxicity of statins. Interindividual differences in the activities of hepatic membrane drug transporters and metabolic enzymes are known to influence statin plasma pharmacokinetics and risk for myopathy. Interestingly, little is known regarding the molecular determinants of statin distribution into skeletal muscle and its relevance to toxicity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCC4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ABCC5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Heptanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Multidrug Resistance-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Anion Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/SLCO2B1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/atorvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance-associated...,
http://linkedlifedata.com/resource/pubmed/chemical/rosuvastatin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1524-4571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
297-306
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pubmed:meshHeading |
pubmed-meshheading:19940267-Cell Survival,
pubmed-meshheading:19940267-Cells, Cultured,
pubmed-meshheading:19940267-Fluorobenzenes,
pubmed-meshheading:19940267-Gene Expression Profiling,
pubmed-meshheading:19940267-HeLa Cells,
pubmed-meshheading:19940267-Heptanoic Acids,
pubmed-meshheading:19940267-Humans,
pubmed-meshheading:19940267-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:19940267-Immunoblotting,
pubmed-meshheading:19940267-Immunohistochemistry,
pubmed-meshheading:19940267-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:19940267-Muscle, Skeletal,
pubmed-meshheading:19940267-Myoblasts,
pubmed-meshheading:19940267-Organic Anion Transporters,
pubmed-meshheading:19940267-Pyrimidines,
pubmed-meshheading:19940267-Pyrroles,
pubmed-meshheading:19940267-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19940267-Sulfonamides
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pubmed:year |
2010
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pubmed:articleTitle |
Human skeletal muscle drug transporters determine local exposure and toxicity of statins.
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pubmed:affiliation |
Department of Physiology & Pharmacology, Department of Medicine, University of Western Ontario, London, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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