| pubmed-article:19934328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19934328 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:19934328 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:19934328 | lifeskim:mentions | umls-concept:C1947901 | lld:lifeskim |
| pubmed-article:19934328 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:19934328 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19934328 | lifeskim:mentions | umls-concept:C1511738 | lld:lifeskim |
| pubmed-article:19934328 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:19934328 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19934328 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19934328 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:19934328 | pubmed:dateCreated | 2009-12-16 | lld:pubmed |
| pubmed-article:19934328 | pubmed:abstractText | By using LNCaP and its derivative cell lines, we first observed an association between tumor necrosis factor-alpha (TNF-alpha) resistance and hormone independence. Moreover, we found that the expression of tumor necrosis factor receptor-associated death domain (TRADD) was reduced in androgen deprivation-independent cells compared with that in androgen deprivation-dependent cells. TRADD is a crucial transducer for TNF-alpha-induced nuclear factor-kappaB (NF-kappaB) activation. Knocking down TRADD expression in LNCaP cells impaired TNF-alpha-induced NF-kappaB activation and androgen receptor repression, whereas overexpression of TRADD in C4-2B cells restored their sensitivity to TNF-alpha. Finally, we found that androgen deprivation reduces TRADD expression in vitro and in vivo, suggesting that androgen deprivation therapy may promote the development of TNF-alpha resistance by reducing TRADD expression during prostate cancer progression. | lld:pubmed |
| pubmed-article:19934328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19934328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19934328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19934328 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19934328 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:19934328 | pubmed:author | pubmed-author:NelsonPeter... | lld:pubmed |
| pubmed-article:19934328 | pubmed:author | pubmed-author:SchmidtLucy... | lld:pubmed |
| pubmed-article:19934328 | pubmed:author | pubmed-author:HuangHaojieH | lld:pubmed |
| pubmed-article:19934328 | pubmed:author | pubmed-author:TindallDonald... | lld:pubmed |
| pubmed-article:19934328 | pubmed:author | pubmed-author:MontgomeryR... | lld:pubmed |
| pubmed-article:19934328 | pubmed:author | pubmed-author:MostaghelElah... | lld:pubmed |
| pubmed-article:19934328 | pubmed:author | pubmed-author:WangDipingD | lld:pubmed |
| pubmed-article:19934328 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19934328 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19934328 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:19934328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19934328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19934328 | pubmed:pagination | 9448-56 | lld:pubmed |
| pubmed-article:19934328 | pubmed:dateRevised | 2011-5-12 | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
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| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:meshHeading | pubmed-meshheading:19934328... | lld:pubmed |
| pubmed-article:19934328 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19934328 | pubmed:articleTitle | Reduced tumor necrosis factor receptor-associated death domain expression is associated with prostate cancer progression. | lld:pubmed |
| pubmed-article:19934328 | pubmed:affiliation | Department of Urology Research/Biochemistry, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. | lld:pubmed |
| pubmed-article:19934328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19934328 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19934328 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
