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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-11-10
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pubmed:abstractText |
The hemostimulatory effects of granulocytic CSF, immobilized on polyethyleneglycol using radiation synthesis nanotechnology, were studied on the model of cyclophosphamide-induced myelosuppression. Immobilization of granulocytic CSF led to stimulation of granulomonocytopoiesis by increasing functional activity of granulomonocytic precursors and secretion of humoral factors by elements of hemopoiesis-inducing microenvironment, and due to more intensive formation of hemopoietic islets. The granulocytopoiesis-stimulating effect of immobilized granulocytic CSF was comparable to the effect of standard nonconjugated granulocytic CSF. Specific activity of immobilized granulocytic CSF in oral treatment was demonstrated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1573-8221
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pubmed:author |
pubmed-author:DygaiA MAM,
pubmed-author:ErmakovaN NNN,
pubmed-author:FirsovaT VTV,
pubmed-author:KhrichkovaT YuTY,
pubmed-author:MadonovP GPG,
pubmed-author:MinakovaM YuMY,
pubmed-author:MiroshnichenkoL ALA,
pubmed-author:SimaninaE VEV,
pubmed-author:StavrovaL ALA,
pubmed-author:UdutE VEV,
pubmed-author:VereshchaginE IEI,
pubmed-author:ZhdanovV VVV,
pubmed-author:Zyuz'kovG NGN
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pubmed:issnType |
Electronic
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pubmed:volume |
148
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-53
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19902095-Animals,
pubmed-meshheading:19902095-Antineoplastic Agents,
pubmed-meshheading:19902095-Bone Marrow,
pubmed-meshheading:19902095-Cyclophosphamide,
pubmed-meshheading:19902095-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:19902095-Granulocytes,
pubmed-meshheading:19902095-Hematopoiesis,
pubmed-meshheading:19902095-Male,
pubmed-meshheading:19902095-Mice,
pubmed-meshheading:19902095-Mice, Inbred CBA,
pubmed-meshheading:19902095-Recombinant Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Mechanisms of granulocytopoiesis-stimulating activity of immobilized granulocytic colony-stimulating factor in cytostatic myelosuppression.
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pubmed:affiliation |
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
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pubmed:publicationType |
Journal Article
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