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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-29
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pubmed:abstractText |
This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (P=0.04) and multivariable analysis (P=0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1873-5835
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pubmed:author |
pubmed-author:BrandaliseSilvia ReginaSR,
pubmed-author:CortezMaria Angélica AbdalaMA,
pubmed-author:LeeMaria Lúcia de MartinoML,
pubmed-author:Pavoni-FerreiraPriscilaP,
pubmed-author:PetrilliAntonio SérgioAS,
pubmed-author:QueirózRosane Gomes de PaulaRG,
pubmed-author:ScrideliCarlos AlbertoCA,
pubmed-author:ToledoSilvia Regina CaminadaSR,
pubmed-author:ToneLuiz GonzagaLG,
pubmed-author:ValeraElvis TerciET,
pubmed-author:YunesJosé AndresJA,
pubmed-author:da MataJuliana FrançaJF
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pubmed:copyrightInfo |
2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
32-7
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pubmed:meshHeading |
pubmed-meshheading:19875168-Base Sequence,
pubmed-meshheading:19875168-Child,
pubmed-meshheading:19875168-Child, Preschool,
pubmed-meshheading:19875168-DNA Primers,
pubmed-meshheading:19875168-Flow Cytometry,
pubmed-meshheading:19875168-Humans,
pubmed-meshheading:19875168-Infant,
pubmed-meshheading:19875168-Matrix Metalloproteinase 2,
pubmed-meshheading:19875168-Matrix Metalloproteinase 9,
pubmed-meshheading:19875168-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19875168-Prognosis,
pubmed-meshheading:19875168-RNA, Messenger,
pubmed-meshheading:19875168-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:19875168-Tissue Inhibitor of Metalloproteinase-2
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pubmed:year |
2010
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pubmed:articleTitle |
mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia: potential role of TIMP1 as an adverse prognostic factor.
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pubmed:affiliation |
Department of Pediatrics, University of Sao Paulo, Ribeirao Preto, SP, Brazil. scrideli@fmrp.usp.br
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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