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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-10-30
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pubmed:abstractText |
The glycosylphosphatidylinositol (GPI)-anchored epithelial extracellular membrane serine protease prostasin (PRSS8) is expressed abundantly in normal epithelia and essential for terminal epithelial differentiation, but down-regulated in human prostate, breast, and gastric cancers and invasive cancer cell lines. Prostasin is involved in the extracellular proteolytic modulation of the epidermal growth factor receptor (EGFR) and is an invasion suppressor. The aim of this study was to evaluate prostasin expression states in the transitional cell carcinomas (TCC) of the human bladder and in human TCC cell lines.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-11274175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-11433419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-11564615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-11584061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-11774283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-12518323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-1279877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-14991861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-15065602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-15126339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-15939524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-16061697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-16541421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-16638913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-16979735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-17276411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-17471493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-17532063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-17609586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-17726580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-18054338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-18236164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-18316572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-18932242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-19670249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19849847-8734733
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
377
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19849847-Cadherins,
pubmed-meshheading:19849847-Carcinoma, Transitional Cell,
pubmed-meshheading:19849847-Cell Differentiation,
pubmed-meshheading:19849847-Cell Line,
pubmed-meshheading:19849847-DNA Methylation,
pubmed-meshheading:19849847-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19849847-Humans,
pubmed-meshheading:19849847-Serine Endopeptidases,
pubmed-meshheading:19849847-Urinary Bladder,
pubmed-meshheading:19849847-Urinary Bladder Neoplasms,
pubmed-meshheading:19849847-Urothelium
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pubmed:year |
2009
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pubmed:articleTitle |
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
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pubmed:affiliation |
Department of Molecular Biology, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida 32816, USA. lchen@mail.ucf.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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