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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-4
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pubmed:abstractText |
Twenty-eight patients with low-moderate, stable rheumatoid arthritis (RA), under treatment with tumor necrosis factor (TNF) alpha blockers, were immunized at least once with non-adjuvanted trivalent influenza vaccine during three consecutive influenza seasons. Antibodies toward A influenza antigens significantly increased and reached protective levels, still detectable 6 months after vaccination, both in RA patients and healthy controls. Response to B antigen instead was only observed from the second year for healthy controls and in the third year for patients. No significant difference in disease activity and anti-nuclear antibodies was observed as a consequence of vaccine administration, whereas T regulatory cells showed a significant increase 30 days after immunization in RA patients. This study confirms safety of influenza vaccine administration in RA patients treated with TNFalpha blockers. The cohort follow-up revealed the overcoming of poor B vaccine antigen immunogenicity via repeated vaccinations. Finally, protective antibody response was still observed 6 months after vaccination.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antirheumatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Influenza Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFR-Fc fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/adalimumab,
http://linkedlifedata.com/resource/pubmed/chemical/infliximab
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1521-7035
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pubmed:author |
pubmed-author:AmodeoRR,
pubmed-author:BiselliRR,
pubmed-author:CappellaAA,
pubmed-author:D AmelioRR,
pubmed-author:Di MartinoAA,
pubmed-author:Di RosaRR,
pubmed-author:DonatelliII,
pubmed-author:FacchiniMM,
pubmed-author:FerlitoCC,
pubmed-author:GermannWW,
pubmed-author:LaganáAA,
pubmed-author:MilanettiFF,
pubmed-author:NisiniRR,
pubmed-author:Picchianti-DiamantiAA,
pubmed-author:PodestàEE,
pubmed-author:RossiFF,
pubmed-author:SalemiSS,
pubmed-author:TabaccoFF
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
134
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-20
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19846344-Adult,
pubmed-meshheading:19846344-Aged,
pubmed-meshheading:19846344-Antibodies, Monoclonal,
pubmed-meshheading:19846344-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:19846344-Antibodies, Viral,
pubmed-meshheading:19846344-Antigens, Viral,
pubmed-meshheading:19846344-Antirheumatic Agents,
pubmed-meshheading:19846344-Arthritis, Rheumatoid,
pubmed-meshheading:19846344-Cell Separation,
pubmed-meshheading:19846344-Female,
pubmed-meshheading:19846344-Flow Cytometry,
pubmed-meshheading:19846344-Fluorescent Antibody Technique,
pubmed-meshheading:19846344-Humans,
pubmed-meshheading:19846344-Immunoglobulin G,
pubmed-meshheading:19846344-Influenza, Human,
pubmed-meshheading:19846344-Influenza A virus,
pubmed-meshheading:19846344-Influenza B virus,
pubmed-meshheading:19846344-Influenza Vaccines,
pubmed-meshheading:19846344-Male,
pubmed-meshheading:19846344-Middle Aged,
pubmed-meshheading:19846344-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:19846344-T-Lymphocyte Subsets,
pubmed-meshheading:19846344-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Influenza vaccine administration in rheumatoid arthritis patients under treatment with TNFalpha blockers: safety and immunogenicity.
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pubmed:affiliation |
Sapienza Università di Roma, II Facoltà di Medicina e Chirurgia, A.O. S. Andrea, Via di Grottarossa 1039, Roma 00189, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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