Source:http://linkedlifedata.com/resource/pubmed/id/19841523
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2009-10-20
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| pubmed:abstractText |
Instruction. We investigated the correlation between atherosclerosis and tissue and serum levels of endothelin-1 in patients with chronic kidney disease (CKD). MATERIALS AND METHODS. Arterial samples were obtained from 35 patients with CKD during arteriovenous fistula placement. Thirty-one patients with cardiovascular disease who underwent coronary artery bypass graft (CABG) were selected as the atherosclerotic group, and a piece of their aorta punched during CABG was obtained. Also, a small piece of the renal artery was dissected during donation in 24 kidney donors (control group). Tissue endothelin-1 level was measured and atherosclerosis grading was determined by pathologic examination. Serum levels of endothelin-1 were also measured in the three groups. Results. The mean tissue endothelin-1 levels were 10.73+/-7.57 pg/mL, 12.16 +/- 3.95 pg/mL, and 0.93 +/- 1.06 pg/mL in the patients with CKD, those with CABG, and donors, respectively (P < .001). The mean serum endothelin-1 level was 25.23 +/- 15.15 pg/mL in the patients with CKD, 21.13 +/- 17.22 pg/mL in the patients with CABG, and 2.66 +/- 1.51 pg/mL in the donors (P < .001). Atherosclerosis grades correlated with tissue endothelin-1 level (r = 0.823, P < .001) and serum endothelin-1 level (r = 0.608, P < .001) in the patients with CKD. Multiple regression analysis showed tissue endothelin-1 level as the main predicting factor of atherosclerosis (P < .001). CONCLUSIONS. Tissue endothelin-1 concentration is more important than serum endothelin-1 or lipids levels in prediction of atherosclerosis. Thus, blockade of tissue endothelin-1 receptors with its antagonists may prevent atherosclerosis progression.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1735-8582
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| pubmed:author |
pubmed-author:ArganiHassanH,
pubmed-author:BohlouliAbolfazlA,
pubmed-author:BonyadiMohammad RezaMR,
pubmed-author:DussGG,
pubmed-author:FakhrjouAshrafA,
pubmed-author:GharedaghiAbasatA,
pubmed-author:GhojazadehMortezaM,
pubmed-author:GhorbanihaghjoAmirA,
pubmed-author:JavadzadeganHasanH,
pubmed-author:NezamiNarimanN,
pubmed-author:NoshadHamidH,
pubmed-author:SadreddiniShahramS
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| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
203-9
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| pubmed:dateRevised |
2010-6-29
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| pubmed:meshHeading |
pubmed-meshheading:19841523-Adult,
pubmed-meshheading:19841523-Arteriovenous Shunt, Surgical,
pubmed-meshheading:19841523-Atherosclerosis,
pubmed-meshheading:19841523-Case-Control Studies,
pubmed-meshheading:19841523-Cohort Studies,
pubmed-meshheading:19841523-Endothelin-1,
pubmed-meshheading:19841523-Female,
pubmed-meshheading:19841523-Humans,
pubmed-meshheading:19841523-Kidney Failure, Chronic,
pubmed-meshheading:19841523-Male,
pubmed-meshheading:19841523-Middle Aged,
pubmed-meshheading:19841523-Renal Dialysis,
pubmed-meshheading:19841523-Risk Factors
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| pubmed:year |
2009
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| pubmed:articleTitle |
Arterial atherosclerosis in patients with chronic kidney disease and its relationship with serum and tissue endothelin-1. [corrected].
|
| pubmed:affiliation |
Division of Nephrology, Drugs Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. hamidnoshad1@yahoo.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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