rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
22
|
pubmed:dateCreated |
2009-11-2
|
pubmed:abstractText |
Cysteine-dependant aspartyl protease (caspase) activation has been implicated as a part of the signal transduction pathway leading to apoptosis. It has been postulated that caspase-3 inhibition could attenuate cell damage after an ischemic event and thereby providing for a novel neuroprotective treatment for stroke. As part of a program to develop a small molecule inhibitor of caspase-3, a novel series of 3,4-dihydropyrimido(1,2-a)indol-10(2H)-ones (pyrimidoindolones) was identified. The synthesis, biological evaluation and structure-activity relationships of the pyrimidoindolones are described.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
1464-3391
|
pubmed:author |
pubmed-author:AulabaughAnnA,
pubmed-author:ChildersWayne EWE,
pubmed-author:ChongDan CDC,
pubmed-author:CowlingRebeccaR,
pubmed-author:DietrichArleneA,
pubmed-author:DollingsPaul JPJ,
pubmed-author:HarrisonBoyd LBL,
pubmed-author:HavranLisa MLM,
pubmed-author:HumWah-TungWT,
pubmed-author:KapoorBhupeshB,
pubmed-author:MarathiasVasiliosV,
pubmed-author:MosyakLidiaL,
pubmed-author:MoyFranklinF,
pubmed-author:RobichaudAlbert JAJ,
pubmed-author:TawaGregoryG,
pubmed-author:WoodAndrewA,
pubmed-author:XuWeixinW
|
pubmed:issnType |
Electronic
|
pubmed:day |
15
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
7755-68
|
pubmed:meshHeading |
|
pubmed:year |
2009
|
pubmed:articleTitle |
3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3.
|
pubmed:affiliation |
Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA. havranl@wyeth.com
|
pubmed:publicationType |
Journal Article
|