Linked Life Data

19813145

Source:http://linkedlifedata.com/resource/pubmed/id/19813145

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-10-8
pubmed:abstractText
Herein we demonstrate that PC12 cells overexpress human amyloid beta precursor protein bearing double Swedish mutation(AbetaPPsw), showing the phenotype characteristic for Alzheimer's disease (AD). Examination of cells at ultrastructural level revealed the intracellular presence of peptide aggregates. Furthermore, autophagy induction was found to be a hallmark of amyloid beta-induced cytotoxicity. Importantly, autophagic vacuoles were co-localized within amyloid beta (Abeta) deposits. This suggests the involvement of autophagy in amyloid beta-elicited cell degeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1641-4640
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
252-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Ultrastructural evidence of amyloid beta-induced autophagy in PC12 cells.
pubmed:affiliation
Department of Cell Ultrastructure, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. bepaj@wp.pl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't