Linked Life Data

1979558

Source:http://linkedlifedata.com/resource/pubmed/id/1979558

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-1-31
pubmed:abstractText
Control of protofilament number has been investigated using Drosophila wings at a stage when 15-protofilament microtubules assemble under normal conditions. Microtubule nucleation still progressed at the usual microtubule-nucleating sites in the presence of taxol. However, provided taxol was introduced before microtubule nucleation began, few microtubules with 15 protofilaments assembled. Most microtubules were composed of 12 protofilaments (a previously undetected value for Drosophila) or 13 protofilaments (which is the value for microtubules in most eukaryotic cells). Unexpectedly, a comparatively mild challenge to control of nucleation (in vitro wing culture) also promoted assembly of 13-protofilament microtubules. Hence, the microtubule-nucleating sites may possess a relatively labile control specifying 15 protofilaments superimposed upon that for maintaining 13-protofilament fidelity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9533
pubmed:author
pubmed:issnType
Print
pubmed:volume
97 ( Pt 1)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Taxol influences control of protofilament number at microtubule-nucleating sites in Drosophila.
pubmed:affiliation
Department of Biology and Preclinical Medicine, University of St Andrews, Fife, Scotland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't