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rdf:type |
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lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0007303,
umls-concept:C0007452,
umls-concept:C0021760,
umls-concept:C0063717,
umls-concept:C0175677,
umls-concept:C0205252,
umls-concept:C0205263,
umls-concept:C0443254,
umls-concept:C1157788,
umls-concept:C1456820,
umls-concept:C1749467
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pubmed:issue |
10
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pubmed:dateCreated |
2009-10-14
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pubmed:abstractText |
Traumatic joint injury can damage cartilage and release inflammatory cytokines from adjacent joint tissue. The present study was undertaken to study the combined effects of compression injury, tumor necrosis factor alpha (TNFalpha), and interleukin-6 (IL-6) and its soluble receptor (sIL-6R) on immature bovine and adult human knee and ankle cartilage, using an in vitro model, and to test the hypothesis that endogenous IL-6 plays a role in proteoglycan loss caused by a combination of injury and TNFalpha.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:BlakeSimon MSM,
pubmed-author:DiMiccoMichael AMA,
pubmed-author:GrodzinskyAlan JAJ,
pubmed-author:HungHan-HwaHH,
pubmed-author:JamesIan EIE,
pubmed-author:LarkMichael WMW,
pubmed-author:LeeJennifer HJH,
pubmed-author:PlaasAnna H KAH,
pubmed-author:SongXiao-YuXY,
pubmed-author:SuiYihongY,
pubmed-author:VanderploegEric JEJ
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2985-96
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pubmed:meshHeading |
pubmed-meshheading:19790045-Adult,
pubmed-meshheading:19790045-Animals,
pubmed-meshheading:19790045-Ankle Injuries,
pubmed-meshheading:19790045-Biomechanics,
pubmed-meshheading:19790045-Cartilage, Articular,
pubmed-meshheading:19790045-Cattle,
pubmed-meshheading:19790045-Cells, Cultured,
pubmed-meshheading:19790045-Chondrocytes,
pubmed-meshheading:19790045-Disease Models, Animal,
pubmed-meshheading:19790045-Female,
pubmed-meshheading:19790045-Glycosaminoglycans,
pubmed-meshheading:19790045-Humans,
pubmed-meshheading:19790045-Interleukin-6,
pubmed-meshheading:19790045-Joints,
pubmed-meshheading:19790045-Knee Injuries,
pubmed-meshheading:19790045-Male,
pubmed-meshheading:19790045-Middle Aged,
pubmed-meshheading:19790045-Proteoglycans,
pubmed-meshheading:19790045-Receptors, Interleukin-6,
pubmed-meshheading:19790045-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.
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pubmed:affiliation |
Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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