Source:http://linkedlifedata.com/resource/pubmed/id/19775319
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2009-10-21
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| pubmed:abstractText |
We prospectively assessed the evolution of coronary artery calcification (CAC) and osteoprotegerin (OPG) levels after renal transplantation (RT). Eighty-three recipients were followed-up prospectively during 1 year. Blood was collected before (baseline) and after RT for determination of mineral metabolism parameters including OPG. CAC was measured by multidetector computed tomography at transplantation (baseline) and 1 year later. Progression of CAC was defined as a difference between the follow-up square-root transformed volume (SRV) and the baseline SRV >or= 2.5. By multivariate analysis, baseline OPG level, age and low LDL levels were significantly associated with baseline CAC. RT was accompanied by mineral metabolism improvement with a decrease of OPG from 955 [395-5652] to 527 [217-1818] pg/mL and parathyroid hormone from 94 [1-550] to 62 [16-410] pg/mL. Thirty-one percent of patients did not exhibit CAC at baseline. CAC diminished in 14.5%, stabilized in 59.2% and progressed in 26.3% of patients. Baseline CAC was associated with progression (OR 2.92 [1.02-8.36]). No significant association was found between OPG and CAC progression despite a higher baseline OPG level in progressors (1046 [456-3285]) vs. non-progressors (899 [396-5952] pg/mL). CAC at baseline, but not 1 year after RT, is independently associated with baseline OPG; posttransplant CAC progression is predicted by baseline CAC score.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1600-6143
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
9
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2571-9
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| pubmed:meshHeading |
pubmed-meshheading:19775319-Adult,
pubmed-meshheading:19775319-Aged,
pubmed-meshheading:19775319-Calcinosis,
pubmed-meshheading:19775319-Coronary Artery Disease,
pubmed-meshheading:19775319-Disease Progression,
pubmed-meshheading:19775319-Female,
pubmed-meshheading:19775319-Follow-Up Studies,
pubmed-meshheading:19775319-Humans,
pubmed-meshheading:19775319-Kidney Failure, Chronic,
pubmed-meshheading:19775319-Kidney Transplantation,
pubmed-meshheading:19775319-Logistic Models,
pubmed-meshheading:19775319-Male,
pubmed-meshheading:19775319-Middle Aged,
pubmed-meshheading:19775319-Multivariate Analysis,
pubmed-meshheading:19775319-Osteoprotegerin,
pubmed-meshheading:19775319-Parathyroid Hormone,
pubmed-meshheading:19775319-Predictive Value of Tests,
pubmed-meshheading:19775319-Prospective Studies,
pubmed-meshheading:19775319-ROC Curve,
pubmed-meshheading:19775319-Risk Factors,
pubmed-meshheading:19775319-Young Adult
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| pubmed:year |
2009
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| pubmed:articleTitle |
Evolution of coronary artery calcifications following kidney transplantation: relationship with osteoprotegerin levels.
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| pubmed:affiliation |
Department of Biochemistry, University of Montpellier, Montpellier, France.
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| pubmed:publicationType |
Journal Article
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