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rdf:type |
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lifeskim:mentions |
umls-concept:C0002520,
umls-concept:C0031727,
umls-concept:C0079904,
umls-concept:C0109317,
umls-concept:C0235032,
umls-concept:C0301630,
umls-concept:C0311404,
umls-concept:C0338656,
umls-concept:C0599946,
umls-concept:C0752312,
umls-concept:C1150579,
umls-concept:C1333340,
umls-concept:C1366876,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1704259,
umls-concept:C1704263,
umls-concept:C1705767,
umls-concept:C1705791,
umls-concept:C1705987,
umls-concept:C1833235,
umls-concept:C1883709
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-9
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pubmed:abstractText |
Amyloid beta (Abeta)-induced neurotoxicity is a major pathological mechanism of Alzheimer disease (AD). In this study, we investigated the inhibitory effect of l-theanine, a component of green tea (Camellia sinensis), on Abeta(1-42)-induced neuronal cell death and memory impairment. Oral treatment of l-theanine (2 and 4 mg/kg) for 5 weeks in the drinking water of mice, followed by injection of Abeta(1-42) (2 microg/mouse, icv), significantly attenuated Abeta(1-42)-induced memory impairment. Furthermore, l-theanine reduced Abeta(1-42) levels and the accompanying Abeta(1-42)-induced neuronal cell death in the cortex and hippocampus of the brain. Moreover, l-theanine inhibited Abeta(1-42)-induced extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase as well as the activity of nuclear factor kappaB (NF-kappaB). l-Theanine also significantly reduced oxidative protein and lipid damage and the elevation of glutathione levels in the brain. These data suggest that the positive effects of l-theanine on memory may be mediated by suppression of ERK/p38 and NF-kappaB as well as the reduction of macromolecular oxidative damage. Thus, l-theanine may be useful in the prevention and treatment of AD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1873-4596
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pubmed:author |
pubmed-author:BanJung OkJO,
pubmed-author:ChoiIm SeopIS,
pubmed-author:HanSang BaeSB,
pubmed-author:HongJin TaeJT,
pubmed-author:KimTae IlTI,
pubmed-author:LeeYong KyungYK,
pubmed-author:NamSang-YoonSY,
pubmed-author:OhKi WanKW,
pubmed-author:ParkHyoung KookHK,
pubmed-author:ParkSang GiSG,
pubmed-author:YunYoung WonYW
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1601-10
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19766184-Alzheimer Disease,
pubmed-meshheading:19766184-Amyloid beta-Peptides,
pubmed-meshheading:19766184-Animals,
pubmed-meshheading:19766184-Apoptosis,
pubmed-meshheading:19766184-Camellia sinensis,
pubmed-meshheading:19766184-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:19766184-Glutamates,
pubmed-meshheading:19766184-Glutathione,
pubmed-meshheading:19766184-Lipid Peroxidation,
pubmed-meshheading:19766184-Male,
pubmed-meshheading:19766184-Memory Disorders,
pubmed-meshheading:19766184-Mice,
pubmed-meshheading:19766184-Mice, Inbred ICR,
pubmed-meshheading:19766184-NF-kappa B,
pubmed-meshheading:19766184-Neurons,
pubmed-meshheading:19766184-Oxidative Stress,
pubmed-meshheading:19766184-Peptide Fragments,
pubmed-meshheading:19766184-Signal Transduction,
pubmed-meshheading:19766184-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways.
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pubmed:affiliation |
College of Pharmacy and CBITRC, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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