|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2009-11-20
|
|
pubmed:abstractText |
Prolyl hydroxylase domain-containing proteins (PHDs) play pivotal roles in oxygen-sensing system through the regulation of alpha-subunit of hypoxia-inducible factor (HIF), a key transcription factor governing a large set of gene expression to adapt hypoxia. Although tissue hypoxia plays an essential role in maintaining inflammation, the role of PHDs in the inflammatory responses has not been clearly determined. Here, we investigated the role of PHDs in lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha) induction in macrophages.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids, Dicarboxylic,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Egln1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hif1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/PHD1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Procollagen-Proline Dioxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/oxalylglycine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1524-4636
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
29
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2132-7
|
|
pubmed:meshHeading |
pubmed-meshheading:19762779-Amino Acids, Dicarboxylic,
pubmed-meshheading:19762779-Animals,
pubmed-meshheading:19762779-Cell Line,
pubmed-meshheading:19762779-Cytokines,
pubmed-meshheading:19762779-Enzyme Inhibitors,
pubmed-meshheading:19762779-Humans,
pubmed-meshheading:19762779-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:19762779-Lipopolysaccharides,
pubmed-meshheading:19762779-Macrophages,
pubmed-meshheading:19762779-Macrophages, Peritoneal,
pubmed-meshheading:19762779-Mice,
pubmed-meshheading:19762779-NF-kappa B,
pubmed-meshheading:19762779-Procollagen-Proline Dioxygenase,
pubmed-meshheading:19762779-RNA Interference,
pubmed-meshheading:19762779-Transcriptional Activation,
pubmed-meshheading:19762779-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19762779-Up-Regulation
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression.
|
|
pubmed:affiliation |
Departments of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
