Source:http://linkedlifedata.com/resource/pubmed/id/19758199
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2009-9-17
|
| pubmed:abstractText |
Specific HLA alleles and immunoregulatory genes have been evaluated in primary biliary cirrhosis (PBC), but data are discordant. We determined whether TNF-alpha promoter polymorphisms (G-308A and G-238A) and alleles of HLA class II (HLA-DRB1) might be associated either with PBC occurrence and severity in Italian populations from two distinct areas. The distribution of TNF1 (G/G) genotype did not differ either between patients and controls or between patients from Northern and Southern Italy. Contrariwise, the HLA-DRB1*08 appeared positively linked to the occurrence of disease (8.4% in patients vs. 2.5% in controls, P = 0.003), whereas the HLA-DRB1*13 appeared to be protective, being more frequent in controls (12.8%) than in patients (7%) (P = 0.038). Neither positively nor negatively associated alleles of the two genomic loci had an effect on disease progression. We report a distinct genetic risk of developing PBC in the Italian population, with no interaction between the HLA and TNF alleles.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1749-6632
|
| pubmed:author |
pubmed-author:AndriulliAngeloA,
pubmed-author:BernuzziFrancescaF,
pubmed-author:BianchiIlariaI,
pubmed-author:CaliariLisaL,
pubmed-author:FontanaRosannaR,
pubmed-author:GioffredaDomenicaD,
pubmed-author:InvernizziPietroP,
pubmed-author:NiroGrazia AnnaGA,
pubmed-author:PoddaMauroM,
pubmed-author:PoliFrancescaF,
pubmed-author:ValvanoMaria RosaMR
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
1173
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
557-63
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:19758199-Adult,
pubmed-meshheading:19758199-Aged,
pubmed-meshheading:19758199-Alleles,
pubmed-meshheading:19758199-Disease Progression,
pubmed-meshheading:19758199-Female,
pubmed-meshheading:19758199-Gene Frequency,
pubmed-meshheading:19758199-Genotype,
pubmed-meshheading:19758199-Geography,
pubmed-meshheading:19758199-HLA-DR Antigens,
pubmed-meshheading:19758199-HLA-DRB1 Chains,
pubmed-meshheading:19758199-Humans,
pubmed-meshheading:19758199-Italy,
pubmed-meshheading:19758199-Liver Cirrhosis, Biliary,
pubmed-meshheading:19758199-Male,
pubmed-meshheading:19758199-Middle Aged,
pubmed-meshheading:19758199-Polymerase Chain Reaction,
pubmed-meshheading:19758199-Polymorphism, Genetic,
pubmed-meshheading:19758199-Promoter Regions, Genetic,
pubmed-meshheading:19758199-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
TNF-alpha polymorphisms in primary biliary cirrhosis: a northern and southern Italian experience.
|
| pubmed:affiliation |
Division of Gastroenterology, Casa Sollievo Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy.
|
| pubmed:publicationType |
Journal Article,
Multicenter Study
|