Linked Life Data

1974035

Source:http://linkedlifedata.com/resource/pubmed/id/1974035

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6283
pubmed:dateCreated
1990-9-6
pubmed:abstractText
The first phase of embryonic development in Drosophila consists of the elaboration and interpretation of maternally encoded information that specifies spatial pattern in the embryo. The product of the maternal gene bicoid (bcd) is thought to organize the anterior pattern of the embryo. Although the bcd transcript is localized at the anterior pole of the egg the bcd protein forms a stable concentration gradient through the anterior two thirds of the embryo. The graded distribution of bcd protein defines position along the anterior-posterior axis of the embryo through the spatially restricted activation of subordinate targets such as the gap gene hunchback (hb). In vitro manipulation of specific bcd protein binding sites has shown that the gradient of bcd protein can in principle define more than one discrete domain of spatially restricted gene activation in the head of the embryo, depending on the affinity of the available binding sites for the bcd protein. Genetic analysis has indicated the need for at least one additional zygotic segmentation gene to mediate bcd function in portions of the head that lie anterior to the hb domain. The missing gene activity is expected to be activated in response to higher levels of bcd protein than are required for hb activation. We report here that three previously identified zygotic genes buttonhead (btd), empty spiracles (ems) and orthodenticle (otd) may behave like gap genes that mediate bcd function in the embryonic head.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
346
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
482-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Mediation of Drosophila head development by gap-like segmentation genes.
pubmed:affiliation
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't