Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-12-7
pubmed:abstractText
Histamine H(2) receptor antagonists have been reported to improve the motor symptoms of Parkinson's disease (PD) patients and to exert neuroprotective effects. In this study, we investigated the protective effects of the H(2) receptor antagonist ranitidine on rotenone-induced apoptosis in human dopaminergic SH-SY5Y cells, focusing on mitogen-activated protein kinases (MAPKs) and caspases (CASPs)-mediated apoptotic events. Ranitidine blocked the rotenone-induced phosphorylation of c-Jun NH(2)-terminal protein kinase (JNK) and P38 MAPK (P38), and promoted the phosphorylation of extracellular signal-regulated protein kinase (ERK). Ranitidine also prevented the down-regulation of B-cell CLL/lymphoma 2 (BCL2) and the up-regulation of BCL2-associated X protein (BAX) by rotenone. Furthermore, ranitidine not only attenuated rotenone-induced cleavages of CASP9, poly(ADP-ribose) polymerase-1 (PARP) and CASP3, but also suppressed CASP3 enzyme activity. These results indicate that ranitidine protects against rotenone-induced apoptosis, inhibiting phosphorylation of JNK and P38, and activation of CASPs in human dopaminergic SH-SY5Y cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CASP9 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9, http://linkedlifedata.com/resource/pubmed/chemical/DAPI, http://linkedlifedata.com/resource/pubmed/chemical/Histamine H2 Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Insecticides, http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein..., http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2, http://linkedlifedata.com/resource/pubmed/chemical/Ranitidine, http://linkedlifedata.com/resource/pubmed/chemical/Rotenone, http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein, http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1872-9711
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1114-9
pubmed:meshHeading
pubmed-meshheading:19723537-Analysis of Variance, pubmed-meshheading:19723537-Apoptosis, pubmed-meshheading:19723537-Caspase 3, pubmed-meshheading:19723537-Caspase 9, pubmed-meshheading:19723537-Cell Survival, pubmed-meshheading:19723537-Dose-Response Relationship, Drug, pubmed-meshheading:19723537-Histamine H2 Antagonists, pubmed-meshheading:19723537-Humans, pubmed-meshheading:19723537-In Situ Nick-End Labeling, pubmed-meshheading:19723537-Indoles, pubmed-meshheading:19723537-Insecticides, pubmed-meshheading:19723537-JNK Mitogen-Activated Protein Kinases, pubmed-meshheading:19723537-Mitogen-Activated Protein Kinases, pubmed-meshheading:19723537-Neuroblastoma, pubmed-meshheading:19723537-Phosphorylation, pubmed-meshheading:19723537-Poly(ADP-ribose) Polymerases, pubmed-meshheading:19723537-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:19723537-Ranitidine, pubmed-meshheading:19723537-Rotenone, pubmed-meshheading:19723537-Up-Regulation, pubmed-meshheading:19723537-bcl-2-Associated X Protein, pubmed-meshheading:19723537-p38 Mitogen-Activated Protein Kinases
pubmed:year
2009
pubmed:articleTitle
Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis.
pubmed:affiliation
Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't