Source:http://linkedlifedata.com/resource/pubmed/id/19708949
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-11-2
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| pubmed:abstractText |
Removal of residual masses after chemotherapy in non-seminomatous germ cell tumours (NSGCTs) remains the standard of care. We evaluated in a retrospective and monocentric study potential prognostic factors. Fifty-one patients underwent surgery after chemotherapy for NSGCT. We estimated event-free survival with Kaplan-Meier method and used Cox proportional hazards regression analysis to assess the prognostic significance of risk factors. Histology of residual masses revealed fibrosis in 25 (49%), mature teratoma in 18 (35%) and viable germ cells in 8 (16%). Alpha-fetoprotein mean level at diagnosis was higher in patients with residual masses showing mature teratoma and/or viable malignant cells (P = 0.036). In multivariate analysis, poor prognosis group according to International Germ Cell Cancer Collaborative Group was associated with worse outcome compared with good and intermediate prognosis groups (hazard ratio for events = 26.4; 95% confidence interval 2.46-283.9; P = 0.006) and primary testicular NSGCT was associated with better event-free survival than extragonadal NSGCTs (hazard ratio for events = 0.04; 95% confidence interval 0.004-0.48; P = 0.01). Resection of residual masses after chemotherapy in NSGCT results in favourable long-term survival in most patients. Our results compared favourably with those reported from higher volume centres.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
N
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1365-2354
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| pubmed:author | |
| pubmed:copyrightInfo |
© 2009 The Authors. European Journal of Cancer Care © 2009 Blackwell Publishing Ltd.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
19
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
827-32
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| pubmed:meshHeading |
pubmed-meshheading:19708949-Adolescent,
pubmed-meshheading:19708949-Adult,
pubmed-meshheading:19708949-Antineoplastic Agents,
pubmed-meshheading:19708949-Disease-Free Survival,
pubmed-meshheading:19708949-Humans,
pubmed-meshheading:19708949-Kaplan-Meier Estimate,
pubmed-meshheading:19708949-Male,
pubmed-meshheading:19708949-Middle Aged,
pubmed-meshheading:19708949-Multivariate Analysis,
pubmed-meshheading:19708949-Neoplasm, Residual,
pubmed-meshheading:19708949-Neoplasms, Germ Cell and Embryonal,
pubmed-meshheading:19708949-Outcome Assessment (Health Care),
pubmed-meshheading:19708949-Prognosis,
pubmed-meshheading:19708949-Proportional Hazards Models,
pubmed-meshheading:19708949-Retrospective Studies,
pubmed-meshheading:19708949-Risk Factors,
pubmed-meshheading:19708949-Testicular Neoplasms,
pubmed-meshheading:19708949-Young Adult
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Resection of residual masses after chemotherapy for advanced non-seminomatous germ cell tumours, a monocentric analysis of pre-operative prognosticators.
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| pubmed:affiliation |
Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France. jldeville@infonie.fr
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| pubmed:publicationType |
Journal Article
|