19695080

Source:http://linkedlifedata.com/resource/pubmed/id/19695080

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0010453, umls-concept:C0017973, umls-concept:C0019134, umls-concept:C0021641, umls-concept:C0225336, umls-concept:C0348080, umls-concept:C0392747, umls-concept:C0443172, umls-concept:C1280500
pubmed:dateCreated	2009-9-9
pubmed:abstractText	Heparan sulfate proteoglycans (HSPGs) contain glycosaminoglycan (GAG) chains made primarily of heparan sulfate (HS). Hyperglycemia in diabetes leads to endothelial injury and nephropathy, retinopathy and atherosclerosis. Decreased HSPG may contribute to diabetic endothelial injury. Decreased tissue HS in diabetes has been reported, however, endothelial HS changes are poorly studied.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101147637
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Glucose, http://linkedlifedata.com/resource/pubmed/chemical/Glycosaminoglycans, http://linkedlifedata.com/resource/pubmed/chemical/Heparan Sulfate Proteoglycans, http://linkedlifedata.com/resource/pubmed/chemical/Heparin, http://linkedlifedata.com/resource/pubmed/chemical/Heparitin Sulfate, http://linkedlifedata.com/resource/pubmed/chemical/Insulin, http://linkedlifedata.com/resource/pubmed/chemical/Syndecans, http://linkedlifedata.com/resource/pubmed/chemical/perlecan
pubmed:status	MEDLINE
pubmed:issn	1475-2840
pubmed:author	pubmed-author:HanJuyingJ, pubmed-author:HiebertLinda MLM, pubmed-author:LinhardtRobert JRJ, pubmed-author:TUIP CPC, pubmed-author:ZhangFumingF
pubmed:issnType	Electronic
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	46
pubmed:dateRevised	2011-11-17
pubmed:meshHeading	pubmed-meshheading:19695080-Animals, pubmed-meshheading:19695080-Cells, Cultured, pubmed-meshheading:19695080-Drug Interactions, pubmed-meshheading:19695080-Electrophoresis, Agar Gel, pubmed-meshheading:19695080-Endothelial Cells, pubmed-meshheading:19695080-Glucose, pubmed-meshheading:19695080-Glycosaminoglycans, pubmed-meshheading:19695080-Heparan Sulfate Proteoglycans, pubmed-meshheading:19695080-Heparin, pubmed-meshheading:19695080-Heparitin Sulfate, pubmed-meshheading:19695080-Insulin, pubmed-meshheading:19695080-Sus scrofa, pubmed-meshheading:19695080-Swine, pubmed-meshheading:19695080-Syndecans, pubmed-meshheading:19695080-Time Factors
pubmed:year	2009
pubmed:articleTitle	Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin.
pubmed:affiliation	Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada. juh884@mail.usask.ca
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't