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rdf:type |
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lifeskim:mentions |
umls-concept:C0036572,
umls-concept:C0037083,
umls-concept:C0206518,
umls-concept:C1334478,
umls-concept:C1516044,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1707798,
umls-concept:C1709061,
umls-concept:C1710082,
umls-concept:C1880352
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pubmed:issue |
3
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pubmed:dateCreated |
2010-3-24
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pubmed:abstractText |
Past work has demonstrated that kainic acid (KA)-induced seizures could cause the enhancement of excitation and lead to neuronal death in rat hippocampus. To counteract such an imbalance between excitation and inhibition, we designed experiments by activating the inhibitory gamma-aminobutyric acid (GABA) receptor to investigate whether such activation suppresses the excitatory glutamate signaling induced by KA and to elucidate the underlying molecular mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Baclofen,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Gluk2 kainate receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 10,
http://linkedlifedata.com/resource/pubmed/chemical/Muscimol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1528-1167
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
391-403
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pubmed:meshHeading |
pubmed-meshheading:19694794-Animals,
pubmed-meshheading:19694794-Apoptosis,
pubmed-meshheading:19694794-Baclofen,
pubmed-meshheading:19694794-Disease Models, Animal,
pubmed-meshheading:19694794-GABA Agonists,
pubmed-meshheading:19694794-Humans,
pubmed-meshheading:19694794-Immunohistochemistry,
pubmed-meshheading:19694794-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:19694794-Kainic Acid,
pubmed-meshheading:19694794-MAP Kinase Kinase Kinases,
pubmed-meshheading:19694794-Male,
pubmed-meshheading:19694794-Membrane Proteins,
pubmed-meshheading:19694794-Mitogen-Activated Protein Kinase 10,
pubmed-meshheading:19694794-Muscimol,
pubmed-meshheading:19694794-Rats,
pubmed-meshheading:19694794-Rats, Sprague-Dawley,
pubmed-meshheading:19694794-Receptors, GABA,
pubmed-meshheading:19694794-Receptors, GABA-A,
pubmed-meshheading:19694794-Receptors, Kainic Acid,
pubmed-meshheading:19694794-Seizures
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pubmed:year |
2010
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pubmed:articleTitle |
Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure.
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pubmed:affiliation |
Research Center of Biochemistry and Molecular Biology, Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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