| pubmed-article:1965895 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1965895 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:1965895 | lifeskim:mentions | umls-concept:C0018338 | lld:lifeskim |
| pubmed-article:1965895 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:1965895 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1965895 | lifeskim:mentions | umls-concept:C0445550 | lld:lifeskim |
| pubmed-article:1965895 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:1965895 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:1965895 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1965895 | pubmed:dateCreated | 1991-7-26 | lld:pubmed |
| pubmed-article:1965895 | pubmed:abstractText | Macrophage-derived PGE2 is usually considered to be a down-regulator of TNF-alpha production. However, we recently demonstrated that PGE2 may display dual activities in that low concentrations stimulated whereas higher doses suppressed TNF-alpha synthesis in resident peritoneal macrophages. To examine the underlying molecular mechanisms, we studied TNF-alpha gene expression in rat peritoneal macrophages and the murine PU5-1.8 macrophage line. In both macrophage types, PGE2 enhanced TNF-alpha gene transcription and production at an optimal concentration of 1 ng/ml. Furthermore, evidence was obtained that PGE2 may stimulate TNF-alpha mRNA accumulation via a rise of the intracellular messenger cGMP. Both, exogenously added as well as endogenously, by sodium nitroprusside generated cGMP were found to enhance TNF-alpha gene expression and production. These findings lend further support to the concept that cGMP may represent one of the positive signals for TNF-alpha synthesis. | lld:pubmed |
| pubmed-article:1965895 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1965895 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965895 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1965895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1965895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965895 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1965895 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1965895 | pubmed:issn | 0171-2985 | lld:pubmed |
| pubmed-article:1965895 | pubmed:author | pubmed-author:GemsaDD | lld:pubmed |
| pubmed-article:1965895 | pubmed:author | pubmed-author:NairII | lld:pubmed |
| pubmed-article:1965895 | pubmed:author | pubmed-author:SprengerHH | lld:pubmed |
| pubmed-article:1965895 | pubmed:author | pubmed-author:RenzHH | lld:pubmed |
| pubmed-article:1965895 | pubmed:author | pubmed-author:HERZM IMI | lld:pubmed |
| pubmed-article:1965895 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1965895 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:1965895 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1965895 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1965895 | pubmed:pagination | 44-55 | lld:pubmed |
| pubmed-article:1965895 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1965895 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1965895 | pubmed:articleTitle | Enhancement of tumor necrosis factor-alpha gene expression by low doses of prostaglandin E2 and cyclic GMP. | lld:pubmed |
| pubmed-article:1965895 | pubmed:affiliation | Institute of Immunology, Philipps University, Marburg, Germany. | lld:pubmed |
| pubmed-article:1965895 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1965895 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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