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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-7-30
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pubmed:abstractText |
In-vitro expansion of functional beta cells from adult human islets is an attractive approach for generating an abundant source of cells for beta-cell replacement therapy of diabetes. Using genetic cell-lineage tracing we have recently shown that beta cells cultured from adult human islets undergo rapid dedifferentiation and proliferate for up to 16 population doublings. These cells have raised interest as potential candidates for redifferentiation into functional insulin-producing cells. Previous work has associated dedifferentiation of cultured epithelial cells with epithelial-mesenchymal transition (EMT), and suggested that EMT generates cells with stem cell properties. Here we investigated the occurrence of EMT in these cultures and assessed their stem cell potential.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-10331405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-15129273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-15153430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-15564314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-16402034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-16446152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-16461897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-16638909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-16824015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-16955247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-17110468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-17303800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-17327438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-17363142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-17488631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-17612586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-17615265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-17786244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-17901402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-18083786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-18211961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-18316362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-18485877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-18599525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-19001380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-19276344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-7589854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19641613-9177395
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e6417
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19641613-Adipocytes,
pubmed-meshheading:19641613-Adult,
pubmed-meshheading:19641613-Base Sequence,
pubmed-meshheading:19641613-Cell Differentiation,
pubmed-meshheading:19641613-Cell Lineage,
pubmed-meshheading:19641613-Cell Proliferation,
pubmed-meshheading:19641613-DNA Primers,
pubmed-meshheading:19641613-Epithelial Cells,
pubmed-meshheading:19641613-Flow Cytometry,
pubmed-meshheading:19641613-Fluorescent Antibody Technique,
pubmed-meshheading:19641613-Humans,
pubmed-meshheading:19641613-Islets of Langerhans,
pubmed-meshheading:19641613-Mesoderm,
pubmed-meshheading:19641613-Osteocytes
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pubmed:year |
2009
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pubmed:articleTitle |
Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells.
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pubmed:affiliation |
Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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