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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-29
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pubmed:abstractText |
TEL-AML1 is an oncogenic fusion protein associated with childhood pre-B acute lymphoblastic leukaemia. From published microarray datasets we identified the Rho Guanine Nucleotide Exchange Factor (RhoGEF) Asef to be associated with TEL-AML1 leukaemia. However, the Asef gene is not a direct target of TEL-AML1 transcriptional control. Forced expression of Asef in vitro induced and maintained proliferation of haemaopoietic progenitor cells and co-operated with TEL-AML1 greatly to enhance proliferation and haemopoietic colony size. In haemopoietic transplantation reconstitution assays Asef and TEL-AML1 together failed to induce a leukaemic phenotype.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1873-5835
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pubmed:author |
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pubmed:copyrightInfo |
2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-15
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pubmed:meshHeading |
pubmed-meshheading:19628279-3T3 Cells,
pubmed-meshheading:19628279-Animals,
pubmed-meshheading:19628279-Cell Transformation, Neoplastic,
pubmed-meshheading:19628279-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:19628279-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:19628279-Hematopoietic Stem Cells,
pubmed-meshheading:19628279-Humans,
pubmed-meshheading:19628279-Leukemia,
pubmed-meshheading:19628279-Mice,
pubmed-meshheading:19628279-Oncogene Proteins, Fusion
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pubmed:year |
2010
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pubmed:articleTitle |
The RAC specific guanine nucleotide exchange factor Asef functions downstream from TEL-AML1 to promote leukaemic transformation.
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pubmed:affiliation |
Unit of Molecular Haematology and Cancer Biology, University College London Institute of Child Health, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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