Source:http://linkedlifedata.com/resource/pubmed/id/19624695
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2009-10-5
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| pubmed:abstractText |
We hypothesized that interleukin-6 (IL-6) in plasma and bronchoalveolar lavage (BAL) might serve as additional diagnostic parameter in lung transplant patients with human cytomegalovirus (HCMV) infection. Therefore, we compared IL-6 levels in HCMV-positive vs. HCMV-negative patients. IL-6 was measured by ELISA in plasma and BAL in 111 patients. Furthermore, we investigated the influence of IL-10 on IL-6 production in HCMV-positive patients. For HCMV-DNA detection in plasma and BAL a quantitative polymerase chain reaction (PCR) assay was used. IL-6 levels were significantly higher in the HCMV-positive group (n = 39; BAL p = 0.045; plasma p = 0.017) in comparison to the HCMV-negative group (n = 72). IL-10 did not correlate with IL-6 concentration (p = 0.146). Donor (D) or recipient (R) HCMV-constellation did not influence IL-6 concentration. IL-6 levels were not influenced by elevated levels of HCMV copies. Our data suggest that IL-6 does not serve as a good diagnostic parameter for existence of HCMV infection in lung transplant patients. Because of the wide range of the IL-6 levels in both groups, we were not able to find a breakpoint differentiating between infected and not-infected patients. Another important finding was that IL-6 production is not dependent of the HCMV status of D/R.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1399-0012
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
687-91
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| pubmed:meshHeading |
pubmed-meshheading:19624695-Adolescent,
pubmed-meshheading:19624695-Adult,
pubmed-meshheading:19624695-Aged,
pubmed-meshheading:19624695-Biological Markers,
pubmed-meshheading:19624695-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:19624695-Cytomegalovirus,
pubmed-meshheading:19624695-Cytomegalovirus Infections,
pubmed-meshheading:19624695-DNA, Viral,
pubmed-meshheading:19624695-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19624695-Female,
pubmed-meshheading:19624695-Humans,
pubmed-meshheading:19624695-Interleukin-10,
pubmed-meshheading:19624695-Interleukin-6,
pubmed-meshheading:19624695-Lung Transplantation,
pubmed-meshheading:19624695-Male,
pubmed-meshheading:19624695-Middle Aged,
pubmed-meshheading:19624695-Polymerase Chain Reaction,
pubmed-meshheading:19624695-Prognosis,
pubmed-meshheading:19624695-Treatment Outcome,
pubmed-meshheading:19624695-Young Adult
|
| pubmed:articleTitle |
Evaluation of interleukin-6 and interleukin-10 in lung transplant patients with human cytomegalovirus infection.
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| pubmed:affiliation |
Intensive Care Unit, Department of Internal Medicine I, Medical University, Vienna, Austria.
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| pubmed:publicationType |
Journal Article,
Evaluation Studies
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