Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-10-5
pubmed:abstractText
We hypothesized that interleukin-6 (IL-6) in plasma and bronchoalveolar lavage (BAL) might serve as additional diagnostic parameter in lung transplant patients with human cytomegalovirus (HCMV) infection. Therefore, we compared IL-6 levels in HCMV-positive vs. HCMV-negative patients. IL-6 was measured by ELISA in plasma and BAL in 111 patients. Furthermore, we investigated the influence of IL-10 on IL-6 production in HCMV-positive patients. For HCMV-DNA detection in plasma and BAL a quantitative polymerase chain reaction (PCR) assay was used. IL-6 levels were significantly higher in the HCMV-positive group (n = 39; BAL p = 0.045; plasma p = 0.017) in comparison to the HCMV-negative group (n = 72). IL-10 did not correlate with IL-6 concentration (p = 0.146). Donor (D) or recipient (R) HCMV-constellation did not influence IL-6 concentration. IL-6 levels were not influenced by elevated levels of HCMV copies. Our data suggest that IL-6 does not serve as a good diagnostic parameter for existence of HCMV infection in lung transplant patients. Because of the wide range of the IL-6 levels in both groups, we were not able to find a breakpoint differentiating between infected and not-infected patients. Another important finding was that IL-6 production is not dependent of the HCMV status of D/R.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1399-0012
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
687-91
pubmed:meshHeading
pubmed-meshheading:19624695-Adolescent, pubmed-meshheading:19624695-Adult, pubmed-meshheading:19624695-Aged, pubmed-meshheading:19624695-Biological Markers, pubmed-meshheading:19624695-Bronchoalveolar Lavage Fluid, pubmed-meshheading:19624695-Cytomegalovirus, pubmed-meshheading:19624695-Cytomegalovirus Infections, pubmed-meshheading:19624695-DNA, Viral, pubmed-meshheading:19624695-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:19624695-Female, pubmed-meshheading:19624695-Humans, pubmed-meshheading:19624695-Interleukin-10, pubmed-meshheading:19624695-Interleukin-6, pubmed-meshheading:19624695-Lung Transplantation, pubmed-meshheading:19624695-Male, pubmed-meshheading:19624695-Middle Aged, pubmed-meshheading:19624695-Polymerase Chain Reaction, pubmed-meshheading:19624695-Prognosis, pubmed-meshheading:19624695-Treatment Outcome, pubmed-meshheading:19624695-Young Adult
pubmed:articleTitle
Evaluation of interleukin-6 and interleukin-10 in lung transplant patients with human cytomegalovirus infection.
pubmed:affiliation
Intensive Care Unit, Department of Internal Medicine I, Medical University, Vienna, Austria.
pubmed:publicationType
Journal Article, Evaluation Studies