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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-5
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pubmed:abstractText |
The identification of useful markers for early diagnosis of human colon cancer is a major goal still in progress. Clusterin is a pleiotropic protein with a broad range of functions. It has recently drawn much attention because of its association with cancer promotion and metastasis. It is involved in prosurvival and apoptosis processes that are carried out by two different isoforms. Secreted clusterin isoform (sCLU) is cytoprotective and its prosurvival function is the basis of the current phase I/II clinical trials against prostate, lung, and breast cancers. We have already shown that in colorectal cancer (CRC) there is an increased expression of sCLU. In this report, we investigated whether sCLU is released in the blood and stool of colon cancer patients in order to study sCLU as a potential diagnostic molecular marker for colon cancer screening.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1572-0241
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2807-15
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pubmed:meshHeading |
pubmed-meshheading:19623170-Adult,
pubmed-meshheading:19623170-Age Distribution,
pubmed-meshheading:19623170-Aged,
pubmed-meshheading:19623170-Aged, 80 and over,
pubmed-meshheading:19623170-Animals,
pubmed-meshheading:19623170-Biopsy, Needle,
pubmed-meshheading:19623170-Blotting, Western,
pubmed-meshheading:19623170-Clusterin,
pubmed-meshheading:19623170-Colonic Neoplasms,
pubmed-meshheading:19623170-Colonoscopy,
pubmed-meshheading:19623170-Colorectal Neoplasms,
pubmed-meshheading:19623170-Early Detection of Cancer,
pubmed-meshheading:19623170-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19623170-Feasibility Studies,
pubmed-meshheading:19623170-Feces,
pubmed-meshheading:19623170-Female,
pubmed-meshheading:19623170-Follow-Up Studies,
pubmed-meshheading:19623170-Humans,
pubmed-meshheading:19623170-Immunohistochemistry,
pubmed-meshheading:19623170-Incidence,
pubmed-meshheading:19623170-Male,
pubmed-meshheading:19623170-Mass Screening,
pubmed-meshheading:19623170-Middle Aged,
pubmed-meshheading:19623170-Pilot Projects,
pubmed-meshheading:19623170-Probability,
pubmed-meshheading:19623170-ROC Curve,
pubmed-meshheading:19623170-Sensitivity and Specificity,
pubmed-meshheading:19623170-Sex Distribution,
pubmed-meshheading:19623170-Statistics, Nonparametric,
pubmed-meshheading:19623170-Tumor Markers, Biological
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pubmed:year |
2009
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pubmed:articleTitle |
Clusterin in stool: a new biomarker for colon cancer screening?
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pubmed:affiliation |
Department of Biopathology, University of Rome Tor Vergata, Rome, Italy. sabina.pucci@uniroma2.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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