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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-9-15
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pubmed:abstractText |
Carbonic anhydrase (CA) IX is suggested to be an endogenous marker of hypoxia. Fluorescent sulfonamides with a high affinity for CA IX (CAI) have been developed and shown to bind to cells only when CA IX protein was expressed and while cells were hypoxic. The aim of this study was to investigate the in vivo CAI binding properties in a xenograft tumour model using fluorescent imaging.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1879-0887
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
423-8
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pubmed:meshHeading |
pubmed-meshheading:19616332-Animals,
pubmed-meshheading:19616332-Antigens, Neoplasm,
pubmed-meshheading:19616332-Binding Sites,
pubmed-meshheading:19616332-Carbonic Anhydrases,
pubmed-meshheading:19616332-Cell Hypoxia,
pubmed-meshheading:19616332-Colorectal Neoplasms,
pubmed-meshheading:19616332-Disease Models, Animal,
pubmed-meshheading:19616332-Female,
pubmed-meshheading:19616332-Fluorescent Antibody Technique,
pubmed-meshheading:19616332-Mice,
pubmed-meshheading:19616332-Mice, Nude,
pubmed-meshheading:19616332-Neoplasm Transplantation,
pubmed-meshheading:19616332-Oxygen,
pubmed-meshheading:19616332-Oxygen Consumption,
pubmed-meshheading:19616332-Probability,
pubmed-meshheading:19616332-Random Allocation,
pubmed-meshheading:19616332-Statistics, Nonparametric,
pubmed-meshheading:19616332-Sulfonamides,
pubmed-meshheading:19616332-Transplantation, Heterologous,
pubmed-meshheading:19616332-Tumor Cells, Cultured,
pubmed-meshheading:19616332-Tumor Markers, Biological
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pubmed:year |
2009
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pubmed:articleTitle |
Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model.
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pubmed:affiliation |
Maastricht Radiation Oncology (MaastRO) Lab, GROW-School for Oncology and Developmental Biology, University of Maastricht, The Netherlands. ludwig.dubois@maastro.unimaas.nl
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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