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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
3
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pubmed:dateCreated |
2009-8-14
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pubmed:abstractText |
CTLA-4 plays a key role in T cells regulation. We analysed the CTLA-4 +49A/G and -318C/T polymorphisms in 178 cases of type 1 diabetes and their parents (534 individuals) from Santiago, Chile. A significant overall association with T1D (p=0.028) was observed, possibly due to an overtransmission of the G-T haplotype.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1872-8227
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
85
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
e34-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19592124-Antigens, CD,
pubmed-meshheading:19592124-CTLA-4 Antigen,
pubmed-meshheading:19592124-Chile,
pubmed-meshheading:19592124-Diabetes Mellitus, Type 1,
pubmed-meshheading:19592124-Exons,
pubmed-meshheading:19592124-Female,
pubmed-meshheading:19592124-Genetic Predisposition to Disease,
pubmed-meshheading:19592124-Humans,
pubmed-meshheading:19592124-Male,
pubmed-meshheading:19592124-Mutation,
pubmed-meshheading:19592124-Odds Ratio,
pubmed-meshheading:19592124-Parents,
pubmed-meshheading:19592124-Polymorphism, Genetic,
pubmed-meshheading:19592124-Polymorphism, Single Nucleotide,
pubmed-meshheading:19592124-Promoter Regions, Genetic,
pubmed-meshheading:19592124-T-Lymphocytes
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pubmed:year |
2009
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|
pubmed:articleTitle |
Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: case-parent design.
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pubmed:affiliation |
Genetic Epidemiology Laboratory, Nutrition and Food Technology Institute (INTA), University of Chile, Santiago, Chile.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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