Linked Life Data

19582768

Source:http://linkedlifedata.com/resource/pubmed/id/19582768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-2-26
pubmed:abstractText
Schizophrenia (SCZ) and bipolar disorder (BPD) are polygenic disorders with many genes contributing to their etiologies. The aim of this investigation was to search for dysregulated molecular and cellular pathways for these disorders as well as psychosis. We conducted a blood-based microarray investigation in two independent samples with SCZ and BPD from San Diego (SCZ = 13, BPD = 9, control = 8) and Taiwan (SCZ = 11, BPD = 14, control = 16). Diagnostic groups were compared to controls, and subjects with a history of psychosis [PSYCH(+): San Diego (n = 6), Taiwan (n = 14)] were compared to subjects without such history [PSYCH(-): San Diego (n = 11), Taiwan (n = 14)]. Analyses of covariance comparing mean expression levels on a gene-by-gene basis were conducted to generate the top 100 significantly dysregulated gene lists for both samples by each diagnostic group. Gene lists were imported into Ingenuity Pathway Analysis (IPA) software. Results showed the ubiquitin proteasome pathway (UPS) was listed in the top ten canonical pathways for BPD and psychosis diagnostic groups across both samples with a considerably low likelihood of a chance occurrence (P = 0.001). No overlap in dysregulated genes populating these pathways was observed between the two independent samples. Findings provide preliminary evidence of UPS dysregulation in BPD and psychosis as well as support further investigation of the UPS and other molecular and cellular pathways for potential biomarkers for SCZ, BPD, and/or psychosis.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/P30MH062512, http://linkedlifedata.com/resource/pubmed/grant/P50MH081755, http://linkedlifedata.com/resource/pubmed/grant/R01 AG018386-09, http://linkedlifedata.com/resource/pubmed/grant/R01 AG022381-09, http://linkedlifedata.com/resource/pubmed/grant/R01AG018386, http://linkedlifedata.com/resource/pubmed/grant/R01AG022381, http://linkedlifedata.com/resource/pubmed/grant/R01AG022982, http://linkedlifedata.com/resource/pubmed/grant/R01DA012846, http://linkedlifedata.com/resource/pubmed/grant/R01DA018662, http://linkedlifedata.com/resource/pubmed/grant/R01MH065562, http://linkedlifedata.com/resource/pubmed/grant/R01MH071912, http://linkedlifedata.com/resource/pubmed/grant/R01MH079881, http://linkedlifedata.com/resource/pubmed/grant/R21MH075027, http://linkedlifedata.com/resource/pubmed/grant/R25MH074508, http://linkedlifedata.com/resource/pubmed/grant/R25MH081482, http://linkedlifedata.com/resource/pubmed/grant/R41MH079728
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1552-485X
pubmed:author
pubmed:copyrightInfo
(c) 2009 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
153B
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
494-502
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: convergent pathway analysis findings from two independent samples.
pubmed:affiliation
Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, La Jolla, CA 92039, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural