| pubmed-article:19580494 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C0032136 | lld:lifeskim |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C0007367 | lld:lifeskim |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:19580494 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:19580494 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19580494 | pubmed:dateCreated | 2009-7-7 | lld:pubmed |
| pubmed-article:19580494 | pubmed:abstractText | To determine whether increased mitochondrially localized catalase was radioprotective, a human catalase transgene was cloned into a small pSVZeo plasmid and localized to the mitochondria of 32D cl 3 cells by adding the mitochondrial localization sequence of MnSOD (mt-catalase). The cell lines 32D-Cat and 32D-mt-Cat had increased catalase biochemical activity as confirmed by Western blot analysis compared to the 32D cl 3 parent cells. The MnSOD-overexpressing 32D cl 3 cell line, 2C6, had decreased baseline catalase activity that was increased in 2C6-Cat and 2C6-mt-Cat subclonal cell lines. 32D-mt-Cat cells were more radioresistant than 32D-Cat cells, but both were radioresistant relative to 32D cl 3 cells. 2C6-mt-Cat cells but not 2C6-Cat cells were radioresistant compared to 2C6 cells. Intratracheal injection of the mt-catalase-plasmid liposome complex (mt-Cat-PL) but not the catalase-plasmid liposome complex (Cat-PL) increased the resistance of C57BL/6NHsd female mice to 20 Gy thoracic irradiation compared to MnSOD-plasmid liposomes. Thus mitochondrially targeted overexpression of the catalase transgene is radioprotective in vitro and in vivo. | lld:pubmed |
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| pubmed-article:19580494 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19580494 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19580494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19580494 | pubmed:month | May | lld:pubmed |
| pubmed-article:19580494 | pubmed:issn | 0033-7587 | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:MelendezJ AJA | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:WangHongH | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:NieSuhuaS | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:EpperlyMichae... | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:GreenbergerJo... | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:DixonTracyT | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:ZhangXichenX | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:PearceLindaL | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:PetersonJames... | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:FranicolaDarc... | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:GreenbergerBe... | lld:pubmed |
| pubmed-article:19580494 | pubmed:author | pubmed-author:KomanduriPaav... | lld:pubmed |
| pubmed-article:19580494 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19580494 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:19580494 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19580494 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19580494 | pubmed:pagination | 588-95 | lld:pubmed |
| pubmed-article:19580494 | pubmed:dateRevised | 2011-5-10 | lld:pubmed |
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