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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-7-2
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pubmed:abstractText |
HIV-infected patients exhibit quantitative and qualitative defects in CD4 T cells, including having increased numbers of CD4+CD45R0+/CD45RA+ T cells, although it remains unclear how these cells arise. Here we demonstrate that gp120 treatment of activated but not resting primary human CD4 T cells decreases number of cells with single positive CD45R0+/CD45RA- effector memory phenotype while proportionally increasing the subset of cells with double positive CD45R0+/CD45RA+ mixed phenotype. We found that double positive CD45R0+/CD45RA+CD4 T cells preferentially undergo apoptosis while single positive CD45R0+/CD45RA- and CD45R0-/CD45RA+ do not. Blocking gp120-CD4 interaction with sCD4 or inhibition Lck activity reverses gp120 induced increase in double positive CD45R0+/CD45RA+CD4 T cells and subsequently diminishes the apoptosis of double positive CD45R0+/CD45RA+ cells. Altogether these data indicate that gp120 ligation of the CD4 receptor increases the number of double positive CD45R0+/CD45RA+ CD4 T cells which subsequently undergo apoptosis in a CD4 dependent manner.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-10357376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-10607709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-11017098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-11095734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-11309627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-11579237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-11714838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-12200381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-12975464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-1451178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-14581610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-15771565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-17141881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-17404265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-1968889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-7678616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-7995936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-8599114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-8617980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-8896418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-9649560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-9792384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19572053-9883844
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pubmed:language |
eng
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pubmed:journal |
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pubmed:status |
PubMed-not-MEDLINE
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pubmed:issn |
1874-3579
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-5
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pubmed:year |
2009
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pubmed:articleTitle |
CD4 T Cells Treated with gp120 Acquire a CD45R0+/CD45RA+ Phenotype.
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pubmed:affiliation |
Division of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article
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