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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-7-28
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pubmed:abstractText |
Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P=0.01) and rs3918342 (P=0.02), and a highly significant under-transmission between haplotype CAT (P=0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1872-7972
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pubmed:author |
pubmed-author:GaoCheng-GeCG,
pubmed-author:GuoTing-WeiTW,
pubmed-author:HuntSS,
pubmed-author:KangWan-HuWH,
pubmed-author:LiuHai-ShengHS,
pubmed-author:LobMM,
pubmed-author:LuShe-MinSM,
pubmed-author:MaXue-HongXH,
pubmed-author:MinZi-XinZX,
pubmed-author:NingQi-LanQL,
pubmed-author:WangShu-HongSH,
pubmed-author:ZhangHuanH,
pubmed-author:ZhangRuiR,
pubmed-author:ZhangYin-CangYC,
pubmed-author:ZhaoWen-XiangWX
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
462
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-8
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pubmed:meshHeading |
pubmed-meshheading:19560517-Adult,
pubmed-meshheading:19560517-Carrier Proteins,
pubmed-meshheading:19560517-Female,
pubmed-meshheading:19560517-Genetic Predisposition to Disease,
pubmed-meshheading:19560517-Genotype,
pubmed-meshheading:19560517-Haplotypes,
pubmed-meshheading:19560517-Humans,
pubmed-meshheading:19560517-Linkage Disequilibrium,
pubmed-meshheading:19560517-Male,
pubmed-meshheading:19560517-Pedigree,
pubmed-meshheading:19560517-Polymerase Chain Reaction,
pubmed-meshheading:19560517-Polymorphism, Single Nucleotide,
pubmed-meshheading:19560517-Schizophrenia
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pubmed:year |
2009
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pubmed:articleTitle |
Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample.
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pubmed:affiliation |
Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, 76 West Yan Ta Rd., Xi'an, Shaanxi, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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