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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-9-1
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pubmed:abstractText |
Phosphatidylinositol 3-OH kinase (PI3K) has a long-recognized role in beta-cell mass regulation and gene transcription and is implicated in the modulation of insulin secretion. The role of nontyrosine kinase receptor-activated PI3K isoforms is largely unexplored. We therefore investigated the role of the G-protein-coupled PI3Kgamma and its catalytic subunit p110gamma in the regulation of insulin granule recruitment and exocytosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-quinoxalin-6-ylmethylenethiazolidi...,
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Class Ib Phosphatidylinositol...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/PIK3CG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pik3cg protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2084-92
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19549714-Actins,
pubmed-meshheading:19549714-Animals,
pubmed-meshheading:19549714-Calcium Channels,
pubmed-meshheading:19549714-Cell Line, Tumor,
pubmed-meshheading:19549714-Class Ib Phosphatidylinositol 3-Kinase,
pubmed-meshheading:19549714-Exocytosis,
pubmed-meshheading:19549714-Humans,
pubmed-meshheading:19549714-Insulin,
pubmed-meshheading:19549714-Insulin-Secreting Cells,
pubmed-meshheading:19549714-Insulinoma,
pubmed-meshheading:19549714-Isoenzymes,
pubmed-meshheading:19549714-Membrane Potentials,
pubmed-meshheading:19549714-Mice,
pubmed-meshheading:19549714-Mice, Inbred C57BL,
pubmed-meshheading:19549714-Mice, Mutant Strains,
pubmed-meshheading:19549714-Pancreatic Neoplasms,
pubmed-meshheading:19549714-Patch-Clamp Techniques,
pubmed-meshheading:19549714-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:19549714-Quinoxalines,
pubmed-meshheading:19549714-RNA, Small Interfering,
pubmed-meshheading:19549714-Secretory Vesicles,
pubmed-meshheading:19549714-Thiazolidinediones
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pubmed:year |
2009
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pubmed:articleTitle |
Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells.
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pubmed:affiliation |
Department of Pharmacology and the Alberta Diabetes Institute, University of Alberta, Alberta, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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