Linked Life Data

Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells.

Source:http://linkedlifedata.com/resource/pubmed/id/19549714

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Authors

Manning Fox JE, Woo M, MacDonald PE, Rückle T, Hoppa MB, Pigeau GM, Kolic J, Ball BJ, Wang YW

Affiliation

Department of Pharmacology and the Alberta Diabetes Institute, University of Alberta, Alberta, Canada.

Abstract

Phosphatidylinositol 3-OH kinase (PI3K) has a long-recognized role in beta-cell mass regulation and gene transcription and is implicated in the modulation of insulin secretion. The role of nontyrosine kinase receptor-activated PI3K isoforms is largely unexplored. We therefore investigated the role of the G-protein-coupled PI3Kgamma and its catalytic subunit p110gamma in the regulation of insulin granule recruitment and exocytosis.

PMID
19549714

Publication types

Research Support, Non-U.S. Gov't