Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2009-6-18
pubmed:abstractText
RGS7, RGS11, and their binding partner Gbeta5 are localized to the dendritic tips of retinal ON bipolar cells (ON-BPC), where mGluR6 responds to glutamate released from photoreceptor terminals by activation of the RGS7/RGS11 substrate, Galphao. To determine their functions in retinal signaling, we investigated cell-specific expression patterns of RGS7 and RGS11 by immunostaining, and measured light responses by electroretinography in mice with targeted disruptions of the genes encoding them. RGS7 staining is present in dendritic tips of all rod ON-BPC, but missing in those for subsets of cone ON-BPC, whereas the converse was true for RGS11 staining. Genetic disruption of either RGS7 or RGS11 produced delays in the ON-BPC-derived electroretinogram b-wave, but no changes in the photoreceptor-derived a-wave. Homozygous RGS7 mutant mice had delays in rod-driven b-waves, whereas RGS11 mutant mice had delays in rod-driven, and especially in cone-driven b-waves. The b-wave delays were further enhanced in mice homozygous for both RGS7 and RGS11 gene disruptions. Thus, RGS7 and RGS11 act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-10066255, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-10191311, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-10491275, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-10564809, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-10676965, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-10824262, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-10854285, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-10870081, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-10966476, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-11008492, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-11124982, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-11262419, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-11784728, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-11829310, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-11997047, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-12077185, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-12231647, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-12686583, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-12732716, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-12738888, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-12818179, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-14578484, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-14702087, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-15215290, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-15488177, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-15534226, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-15535992, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-15573941, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-15728856, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-16553780, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-1681833, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-16839421, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-16908407, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-1706097, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-1714492, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-18001285, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-18079688, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-18094259, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-18388140, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-3025746, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-3026986, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-478786, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-6255566, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-6273752, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-7889569, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-8071339, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-8389366, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-8918908, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-8924408, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-8985127, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-9279006, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-9315921, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-9556034, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-9789084, http://linkedlifedata.com/resource/pubmed/commentcorrection/19535587-9870972
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins, http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha..., http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein beta Subunits, http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C, http://linkedlifedata.com/resource/pubmed/chemical/RGS Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate, http://linkedlifedata.com/resource/pubmed/chemical/Rgs11 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Rgs7 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid, http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 6
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
17
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7753-65
pubmed:dateRevised
2011-5-18
pubmed:meshHeading
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