Source:http://linkedlifedata.com/resource/umls/id/C0633372
MSH: A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.,NCI: RGS family proteins activate GTPase and regulate G protein signaling by stimulating the inactivation of heterotrimeric G proteins. RGS family proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. There are indications that a subset of RGS proteins regulate specific G protein-coupled receptor pathways.