| pubmed-article:19524549 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19524549 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19524549 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:19524549 | lifeskim:mentions | umls-concept:C0005773 | lld:lifeskim |
| pubmed-article:19524549 | lifeskim:mentions | umls-concept:C0162371 | lld:lifeskim |
| pubmed-article:19524549 | lifeskim:mentions | umls-concept:C0020564 | lld:lifeskim |
| pubmed-article:19524549 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19524549 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19524549 | pubmed:dateCreated | 2009-7-6 | lld:pubmed |
| pubmed-article:19524549 | pubmed:abstractText | We have assessed the capacity of human umbilical cord blood (hUCB)-derived stem cells to differentiate into cardiomyocytes and repair angiotensin II induced insult in culture and in mouse hearts when injected. hUCB were able to differentiate into cardiomyocyte-like cells, when induced with 5-azacytidine or co-cultured with rat neonatal cardiomyocytes (NRCM). When co-cultured, hUCB reversed the pathological effects induced by angiotensin II (Ang-II) in NRCM and in mice injected after Ang-II infusion. As assessed by increased heart weight to body mass ratio and Ang-II-induced fibrosis, cardiac hypertrophy was also reduced after hUCB were injected. hUCB also reversed the pathological heart failure markers induced by Ang-II in mice. Further, we observed a shift from pathological hypertrophy towards physiological hypertrophy by hUCB in Ang-II-challenged mice. Our findings support hUCB as a feasible model for experimentation in stem cell therapy and emphasize the relevance of the hUCB in reversing heart failure conditions. | lld:pubmed |
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| pubmed-article:19524549 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19524549 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19524549 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19524549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19524549 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19524549 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19524549 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:19524549 | pubmed:author | pubmed-author:RaoJasti SJS | lld:pubmed |
| pubmed-article:19524549 | pubmed:author | pubmed-author:VanamalaSrava... | lld:pubmed |
| pubmed-article:19524549 | pubmed:author | pubmed-author:GondiChristop... | lld:pubmed |
| pubmed-article:19524549 | pubmed:author | pubmed-author:SreelathaGopi... | lld:pubmed |
| pubmed-article:19524549 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19524549 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:19524549 | pubmed:volume | 386 | lld:pubmed |
| pubmed-article:19524549 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19524549 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19524549 | pubmed:pagination | 386-91 | lld:pubmed |
| pubmed-article:19524549 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
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| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
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| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:meshHeading | pubmed-meshheading:19524549... | lld:pubmed |
| pubmed-article:19524549 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19524549 | pubmed:articleTitle | Effect of human umbilical cord blood cells on Ang-II-induced hypertrophy in mice. | lld:pubmed |
| pubmed-article:19524549 | pubmed:affiliation | Department of Cancer Biology & Pharmacology, University of Illinois, College of Medicine at Peoria, Peoria, IL 61656, USA. | lld:pubmed |
| pubmed-article:19524549 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19524549 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19524549 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
