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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-7-6
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pubmed:abstractText |
We have assessed the capacity of human umbilical cord blood (hUCB)-derived stem cells to differentiate into cardiomyocytes and repair angiotensin II induced insult in culture and in mouse hearts when injected. hUCB were able to differentiate into cardiomyocyte-like cells, when induced with 5-azacytidine or co-cultured with rat neonatal cardiomyocytes (NRCM). When co-cultured, hUCB reversed the pathological effects induced by angiotensin II (Ang-II) in NRCM and in mice injected after Ang-II infusion. As assessed by increased heart weight to body mass ratio and Ang-II-induced fibrosis, cardiac hypertrophy was also reduced after hUCB were injected. hUCB also reversed the pathological heart failure markers induced by Ang-II in mice. Further, we observed a shift from pathological hypertrophy towards physiological hypertrophy by hUCB in Ang-II-challenged mice. Our findings support hUCB as a feasible model for experimentation in stem cell therapy and emphasize the relevance of the hUCB in reversing heart failure conditions.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/CA 116708,
http://linkedlifedata.com/resource/pubmed/grant/CA 75557,
http://linkedlifedata.com/resource/pubmed/grant/CA 92393,
http://linkedlifedata.com/resource/pubmed/grant/CA 95058,
http://linkedlifedata.com/resource/pubmed/grant/CA138409,
http://linkedlifedata.com/resource/pubmed/grant/NS47699,
http://linkedlifedata.com/resource/pubmed/grant/NS57529,
http://linkedlifedata.com/resource/pubmed/grant/NS61835,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA075557-12,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA092393-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA095058-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA116708-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA138409-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS047699-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS057529-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS061835-02
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-10074487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-10358794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-10666070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-10998641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-11731612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-1534087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-15757377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-17004246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-17111039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18081534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18497316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18519547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18549704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18557828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18628208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18657407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18662129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18689869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-18842332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-19074827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-7418319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19524549-9488650
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1090-2104
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
386
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
386-91
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19524549-Angiotensin II,
pubmed-meshheading:19524549-Animals,
pubmed-meshheading:19524549-Apoptosis,
pubmed-meshheading:19524549-Biological Markers,
pubmed-meshheading:19524549-Cardiomegaly,
pubmed-meshheading:19524549-Cell Differentiation,
pubmed-meshheading:19524549-Coculture Techniques,
pubmed-meshheading:19524549-Fetal Blood,
pubmed-meshheading:19524549-Histocompatibility Antigens Class I,
pubmed-meshheading:19524549-Humans,
pubmed-meshheading:19524549-Mice,
pubmed-meshheading:19524549-Myocytes, Cardiac,
pubmed-meshheading:19524549-Rats,
pubmed-meshheading:19524549-Stem Cell Transplantation,
pubmed-meshheading:19524549-Stem Cells
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pubmed:year |
2009
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pubmed:articleTitle |
Effect of human umbilical cord blood cells on Ang-II-induced hypertrophy in mice.
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pubmed:affiliation |
Department of Cancer Biology & Pharmacology, University of Illinois, College of Medicine at Peoria, Peoria, IL 61656, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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