Source:http://linkedlifedata.com/resource/pubmed/id/19509365
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2009-6-17
|
| pubmed:abstractText |
Decision making for treatment of localized prostate cancer is often guided by therapeutic side-effect profiles. We sought to assess health-related quality-of-life outcomes for patients 48 months after treatment for localized prostate cancer. Men treated for localized prostate cancer (N = 475) were evaluated before treatment and at 11 intervals during the 48 months after intervention. Changes in mean health-related quality-of-life scores and the probability of regaining baseline levels of health-related quality of life were compared between treatment groups. All statistical tests were two-sided. Urinary incontinence was more common after prostatectomy (n = 307) than after brachytherapy (n = 90) or external beam radiation therapy (n = 78) (both P < .001), whereas voiding and storage urinary symptoms were more prevalent after brachytherapy than after prostatectomy (both P < .001). Sexual dysfunction profoundly affected all three treatment groups, with a lower likelihood of regaining baseline function after prostatectomy than after external beam radiation therapy or brachytherapy (P < .001). Bowel dysfunction was more common after either form of radiation therapy than after prostatectomy. These results may guide decision making for treatment selection and clinical management of patients with health-related quality-of-life impairments after treatment for localized prostate cancer.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1460-2105
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
16
|
| pubmed:volume |
101
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
888-92
|
| pubmed:meshHeading |
pubmed-meshheading:19509365-Aged,
pubmed-meshheading:19509365-Brachytherapy,
pubmed-meshheading:19509365-Comorbidity,
pubmed-meshheading:19509365-Confounding Factors (Epidemiology),
pubmed-meshheading:19509365-Educational Status,
pubmed-meshheading:19509365-Erectile Dysfunction,
pubmed-meshheading:19509365-Health Status,
pubmed-meshheading:19509365-Humans,
pubmed-meshheading:19509365-Male,
pubmed-meshheading:19509365-Middle Aged,
pubmed-meshheading:19509365-Neoplasm Staging,
pubmed-meshheading:19509365-Prostatectomy,
pubmed-meshheading:19509365-Prostatic Neoplasms,
pubmed-meshheading:19509365-Quality of Life,
pubmed-meshheading:19509365-Questionnaires,
pubmed-meshheading:19509365-Radiation Injuries,
pubmed-meshheading:19509365-Radiotherapy,
pubmed-meshheading:19509365-Survival Analysis,
pubmed-meshheading:19509365-Treatment Outcome,
pubmed-meshheading:19509365-Urinary Incontinence
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Survivorship beyond convalescence: 48-month quality-of-life outcomes after treatment for localized prostate cancer.
|
| pubmed:affiliation |
Robert Wood Johnson Clinical Scholars Program, University of California, Los Angeles, 911 Broxton Avenue, Los Angeles, CA 90024, USA. jgore@mednet.ucla.edu
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|