| pubmed-article:19503107 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C1336692 | lld:lifeskim |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:19503107 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:19503107 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19503107 | pubmed:dateCreated | 2009-6-18 | lld:pubmed |
| pubmed-article:19503107 | pubmed:abstractText | Macrophage colony-stimulating factor (M-CSF) influences the proliferation and survival of mononuclear phagocytes through the receptor CSF-1R. The adaptor protein DAP12 is critical for the function of mononuclear phagocytes. DAP12-mutant mice and humans have defects in osteoclasts and microglia, as well as brain and bone abnormalities. Here we show DAP12 deficiency impaired the M-CSF-induced proliferation and survival of macrophages in vitro. DAP12-deficient mice had fewer microglia in defined central nervous system areas, and DAP12-deficient progenitors regenerated myeloid cells inefficiently after bone marrow transplantation. Signaling by M-CSF through CSF-1R induced the stabilization and nuclear translocation of beta-catenin, which activated genes involved in the cell cycle. DAP12 was essential for phosphorylation and nuclear accumulation of beta-catenin. Our results provide a mechanistic explanation for the many defects of DAP12-deficient mononuclear phagocytes. | lld:pubmed |
| pubmed-article:19503107 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19503107 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19503107 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19503107 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19503107 | pubmed:issn | 1529-2916 | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:TakaiToshiyuk... | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:ColonnaMarcoM | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:ShawAndrey... | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:AoshiTaikiT | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:MillerMarkM | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:VermiWilliamW | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:TassiIlariaI | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:OteroKarelK | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:PolianiPietro... | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:TurnbullIsaia... | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:CeruttiElisaE | lld:pubmed |
| pubmed-article:19503107 | pubmed:author | pubmed-author:StanleySamuel... | lld:pubmed |
| pubmed-article:19503107 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19503107 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:19503107 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19503107 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19503107 | pubmed:pagination | 734-43 | lld:pubmed |
| pubmed-article:19503107 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19503107 | pubmed:meshHeading | pubmed-meshheading:19503107... | lld:pubmed |
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| pubmed-article:19503107 | pubmed:meshHeading | pubmed-meshheading:19503107... | lld:pubmed |
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| pubmed-article:19503107 | pubmed:meshHeading | pubmed-meshheading:19503107... | lld:pubmed |
| pubmed-article:19503107 | pubmed:meshHeading | pubmed-meshheading:19503107... | lld:pubmed |
| pubmed-article:19503107 | pubmed:meshHeading | pubmed-meshheading:19503107... | lld:pubmed |
| pubmed-article:19503107 | pubmed:meshHeading | pubmed-meshheading:19503107... | lld:pubmed |
| pubmed-article:19503107 | pubmed:meshHeading | pubmed-meshheading:19503107... | lld:pubmed |
| pubmed-article:19503107 | pubmed:meshHeading | pubmed-meshheading:19503107... | lld:pubmed |
| pubmed-article:19503107 | pubmed:meshHeading | pubmed-meshheading:19503107... | lld:pubmed |
| pubmed-article:19503107 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19503107 | pubmed:articleTitle | Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin. | lld:pubmed |
| pubmed-article:19503107 | pubmed:affiliation | Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA. | lld:pubmed |
| pubmed-article:19503107 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19503107 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19503107 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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