Linked Life Data

19482681

Source:http://linkedlifedata.com/resource/pubmed/id/19482681

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-6-1
pubmed:abstractText
Reactive oxygen species (ROS) can mediate cellular signal transduction, destroy hazardous foreign pathogens, regulate transcriptional activities and therefore are essential in normal cellular physiology. On the other hand, inadequate control of ROS production can induce peroxidation of essential biomolecules and result in cellular dysfunction. In the worst condition even cell death ensues. Therefore, they have great implications in the initiation and progression of numerous diseases. Chemical instability of ROS limits its direct detection and the dynamics remain poorly studied. To study the ROS dynamics, the endogenous or exogenous redox-sensitive fluorophores provide a good chance to detect the real-time changes in in vivo or in vitro settings. Here these methods are reviewed and their potential applications are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1945-0524
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-44
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Imaging reactive oxygen species dynamics in living cells and tissues.
pubmed:affiliation
Department of Primary Care Medicine, College of Medicine, National Taiwan University, 1 Section 1 Jen-Ai Road, Taipei, Taiwan. chauchungwu@ntu.edu.tw
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't