Linked Life Data

19467928

Source:http://linkedlifedata.com/resource/pubmed/id/19467928

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pubmed-article:19467928pubmed:abstractTextThe effect of Clostridium perfringens alpha-toxin on production of tumor necrosis factor (TNF)-alpha and nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells was studied. The pretreatment of wild type alpha-toxin, but not the inactive mutant, significantly decreased LPS-induced TNF-alpha and NO production. alpha-Toxin inhibited the expression of TNF-alpha and an inducible type of NO synthase protein and mRNA. Furthermore, it inhibited the phosphorylation of IkappaB-alpha and p65 NF-kappaB subunit, and the NF-kappaB luciferase reporter gene activity in LPS-stimulated cells. The pretreatment of alpha-toxin increased the level of intracellular ceramide. Taken together, Clostridium perfringens alpha-toxin pretreatment was suggested to inhibit LPS-induced TNF-alpha and NO production through the inhibition of NF-kappaB activation. The relationship between alpha-toxin-induced intracellular ceramide generation and the NF-kappaB inhibition is discussed.lld:pubmed
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pubmed-article:19467928pubmed:articleTitleThe inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by Clostridium perfringens alpha-toxin and its relation to alpha-toxin-induced intracellular ceramide generation.lld:pubmed
pubmed-article:19467928pubmed:affiliationDepartment of Microbiology and Immunology, Aichi Medical University, School of Medicine, Nagakute, Aichi 480-1195, Japan.lld:pubmed
pubmed-article:19467928pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19467928pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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