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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-6-15
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pubmed:abstractText |
The neurogenic gene Drosophila big brain (bib) has a high sequence homology to aquaporin-4. However, its cellular functions in Drosophila neurogenesis have remained elusive. Here we investigated cell adhesion, and the ion and water permeability of Bib. The adhesive function was examined by a cell aggregation assay using L cells. Bib-transfected L cells formed aggregated clusters, while control-L cells remained as a single cell suspension. Ion permeation was not confirmed in L cells stably expressing Bib. When expressed in COS7 cells, Bib exhibited limited water permeability. This newly found cell adhesive function of Bib may be important for Drosophila neurogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AQP4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Aquaporin 4,
http://linkedlifedata.com/resource/pubmed/chemical/Aquaporins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/bib protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/enhanced green fluorescent protein
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1873-3468
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
583
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2077-82
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pubmed:meshHeading |
pubmed-meshheading:19467350-Animals,
pubmed-meshheading:19467350-Aquaporin 4,
pubmed-meshheading:19467350-Aquaporins,
pubmed-meshheading:19467350-Biotinylation,
pubmed-meshheading:19467350-COS Cells,
pubmed-meshheading:19467350-Cell Adhesion,
pubmed-meshheading:19467350-Cell Membrane,
pubmed-meshheading:19467350-Cercopithecus aethiops,
pubmed-meshheading:19467350-Drosophila Proteins,
pubmed-meshheading:19467350-Gene Expression,
pubmed-meshheading:19467350-Green Fluorescent Proteins,
pubmed-meshheading:19467350-Humans,
pubmed-meshheading:19467350-L Cells (Cell Line),
pubmed-meshheading:19467350-Membrane Proteins,
pubmed-meshheading:19467350-Mice,
pubmed-meshheading:19467350-Patch-Clamp Techniques,
pubmed-meshheading:19467350-Recombinant Fusion Proteins,
pubmed-meshheading:19467350-Transfection
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pubmed:year |
2009
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pubmed:articleTitle |
Drosophila big brain does not act as a water channel, but mediates cell adhesion.
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pubmed:affiliation |
Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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