Linked Life Data

19455515

Source:http://linkedlifedata.com/resource/pubmed/id/19455515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-9-2
pubmed:abstractText
Iron homeostasis is essential to almost all organisms. In this study, we identified the putative homolog of the iron-storage protein-encoding gene, dpsL, in the intracellular pathogen Legionella pneumophila and demonstrated its expression under iron-limited conditions and its responses to multiple stresses. Quantitative real-time PCR analysis indicated that the expression of dpsL was enhanced under iron limitation regardless of the growth phase. Compared with the wild-type cells, the cells devoid of dpsL were heat and H(2)O(2)-sensitive. In contrast to the dps mutants of other bacteria, the growth of the dpsL mutant in an iron-deprived medium was delayed but finally reached the same cell density as wild-type cells during the stationary phase of growth. The finding that the dpsL mutant is salt resistant suggested the involvement of DpsL in virulence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1521-4028
pubmed:author
pubmed:copyrightInfo
Copyright 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
pubmed:issnType
Electronic
pubmed:volume
49 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S79-86
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The Legionella pneumophila Dps homolog is regulated by iron and involved in multiple stress tolerance.
pubmed:affiliation
Department of Biochemistry, Sun Yat-sen University Guangzhou, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't