|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0025914,
umls-concept:C0026336,
umls-concept:C0026339,
umls-concept:C0026809,
umls-concept:C0026882,
umls-concept:C0036572,
umls-concept:C0086418,
umls-concept:C0205349,
umls-concept:C0220669,
umls-concept:C0449864,
umls-concept:C1416614,
umls-concept:C1416615,
umls-concept:C1521828,
umls-concept:C1706701,
umls-concept:C1720776
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|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2010-9-13
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|
pubmed:abstractText |
Benign familial neonatal convulsions (BFNC) is caused by mutations in the KCNQ2 and KCNQ3 genes, which encode subunits of the M-type potassium channel. The purpose of this study was to examine the effects of orthologous BFNC-causing mutations on seizure thresholds and the acquisition of corneal kindling in mice with heterozygous expression of the mutations.
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pubmed:grant |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1528-1167
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|
pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
50
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1752-9
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pubmed:meshHeading |
pubmed-meshheading:19453707-Action Potentials,
pubmed-meshheading:19453707-Animals,
pubmed-meshheading:19453707-Disease Models, Animal,
pubmed-meshheading:19453707-Electric Stimulation,
pubmed-meshheading:19453707-Electrocardiography,
pubmed-meshheading:19453707-Epilepsy, Benign Neonatal,
pubmed-meshheading:19453707-Female,
pubmed-meshheading:19453707-Gene Knock-In Techniques,
pubmed-meshheading:19453707-Genetic Predisposition to Disease,
pubmed-meshheading:19453707-Heterozygote,
pubmed-meshheading:19453707-Humans,
pubmed-meshheading:19453707-KCNQ2 Potassium Channel,
pubmed-meshheading:19453707-KCNQ3 Potassium Channel,
pubmed-meshheading:19453707-Kindling, Neurologic,
pubmed-meshheading:19453707-Male,
pubmed-meshheading:19453707-Mice,
pubmed-meshheading:19453707-Mutation,
pubmed-meshheading:19453707-Mutation, Missense,
pubmed-meshheading:19453707-Nerve Tissue Proteins,
pubmed-meshheading:19453707-Seizures,
pubmed-meshheading:19453707-Sex Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
