Linked Life Data

19433267

Source:http://linkedlifedata.com/resource/pubmed/id/19433267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-5-12
pubmed:abstractText
Phthalates like di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) are commonly used as plasticisers, enteric coatings in medications and their metabolites (MnBP respectively MiBP) are suspect of adverse endocrine activities. The aim of this study was to determine kinetical data in humans after the application of a drug containing 3600 microg of DnBP and to quantify main metabolites of DnBP and DiBP with and without glucuronidase treatment. Since commonly glucuronides do not exhibit endocrine activity it is of interest to determine the potentially active metabolite like free MnBP and MiBP for a valid risk assessment. After the application of one capsule containing 3600 microg of DnBP to 17 volunteers 78% (median of 2248 microg of total MnBP) of administered DnBP was found within 24h in urine. After 24h the levels of MnBP in urine were comparable to concentrations before administration showing a fast elimination. In contrast to controls in all urine samples collected within 24h after the administration of the drug free MnBP was observed with a median of 4% of total MnBP. In controls total MnBP and MiBP were found in median concentration of 23 microg/24h and about 50 microg/24h, respectively and therefore environmental exposure to DnBP is only 1% compared to medication. Since an uptake of 3600 microg in only one capsule is already above the tolerable daily intake (TDI) for DnBP of 10 microg/kg b.w. from a preventive health protection DnBP should be replaced in medical drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1879-3169
pubmed:author
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
188
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-7
pubmed:dateRevised
2009-7-13
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Determination of total and free mono-n-butyl phthalate in human urine samples after medication of a di-n-butyl phthalate containing capsule.
pubmed:affiliation
Bavarian Health and Food Safety Authority, Environmental Medicine/Biomonitoring, Munich, Germany.
pubmed:publicationType
Journal Article, Clinical Trial