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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-5-19
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pubmed:abstractText |
Herein we report a series of novel chloramphenicol amine derivatives as aminopeptidase N (APN)/CD13 inhibitors. All compounds were synthesized starting from commercially available (1S,2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol. The preliminary biological screening showed that some compounds exhibited potent inhibitory activity against APN. It should be noted that one compound, 13b (IC(50)=7.1 microM), possess similar APN inhibitory activity compared with Bestatin (IC(50)=3.0 microM).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3810-7
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pubmed:meshHeading |
pubmed-meshheading:19423354-Amines,
pubmed-meshheading:19423354-Antigens, CD13,
pubmed-meshheading:19423354-Catalytic Domain,
pubmed-meshheading:19423354-Chloramphenicol,
pubmed-meshheading:19423354-Drug Design,
pubmed-meshheading:19423354-Enzyme Activation,
pubmed-meshheading:19423354-HL-60 Cells,
pubmed-meshheading:19423354-Humans,
pubmed-meshheading:19423354-Inhibitory Concentration 50,
pubmed-meshheading:19423354-Leucine,
pubmed-meshheading:19423354-Models, Biological,
pubmed-meshheading:19423354-Molecular Structure,
pubmed-meshheading:19423354-Protease Inhibitors
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pubmed:year |
2009
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pubmed:articleTitle |
Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors.
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pubmed:affiliation |
Department of Medicinal Chemistry, School of Pharmacy, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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