19417026

Source:http://linkedlifedata.com/resource/pubmed/id/19417026

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006142, umls-concept:C0013089, umls-concept:C0033325, umls-concept:C0086418, umls-concept:C0681842, umls-concept:C0752312
pubmed:issue	10
pubmed:dateCreated	2009-5-19
pubmed:abstractText	Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) dephosphorylates mitogen-activated protein kinase [extracellular signal-regulated kinase (ERK), c-Jun NH(2)-terminal kinase (JNK), and p38], mediates breast cancer chemoresistance, and is repressible by doxorubicin in breast cancer cells. We aimed to characterize doxorubicin effects on MKP-1 and phospho-MAPKs in human breast cancers and to further study the clinical relevance of MKP-1 expression in this disease.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic, http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin, http://linkedlifedata.com/resource/pubmed/chemical/Dual Specificity Phosphatase 1, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP..., http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein..., http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	1078-0432
pubmed:author	pubmed-author:AlbanellJoanJ, pubmed-author:BellosilloBeatrizB, pubmed-author:BragadoRafaelR, pubmed-author:CampasClaraC, pubmed-author:CorominasJosep MariaJM, pubmed-author:Cortes-SempereMariaM, pubmed-author:DalmasesAlbaA, pubmed-author:González-NavarreteIreneI, pubmed-author:MenéndezSilviaS, pubmed-author:OlivaCristinaC, pubmed-author:PeronaRosarioR, pubmed-author:Rodriguez-FanjulVanesaV, pubmed-author:RojoFedericoF, pubmed-author:RoviraAnaA, pubmed-author:Sánchez-PérezIsabelI, pubmed-author:SerranoSergiS, pubmed-author:ServitjaSoniaS, pubmed-author:SuárezCristinaC, pubmed-author:TusquetsIgnasiI
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	15
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3530-9
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:19417026-Antibiotics, Antineoplastic, pubmed-meshheading:19417026-Blotting, Western, pubmed-meshheading:19417026-Breast Neoplasms, pubmed-meshheading:19417026-Cell Line, Tumor, pubmed-meshheading:19417026-Cluster Analysis, pubmed-meshheading:19417026-Doxorubicin, pubmed-meshheading:19417026-Dual Specificity Phosphatase 1, pubmed-meshheading:19417026-Extracellular Signal-Regulated MAP Kinases, pubmed-meshheading:19417026-Gene Expression Regulation, Enzymologic, pubmed-meshheading:19417026-Gene Expression Regulation, Neoplastic, pubmed-meshheading:19417026-Humans, pubmed-meshheading:19417026-Immunohistochemistry, pubmed-meshheading:19417026-JNK Mitogen-Activated Protein Kinases, pubmed-meshheading:19417026-Kaplan-Meier Estimate, pubmed-meshheading:19417026-Neoplasm Recurrence, Local, pubmed-meshheading:19417026-Phosphorylation, pubmed-meshheading:19417026-Predictive Value of Tests, pubmed-meshheading:19417026-Prognosis, pubmed-meshheading:19417026-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19417026-p38 Mitogen-Activated Protein Kinases
pubmed:year	2009
pubmed:articleTitle	Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin.
pubmed:affiliation	Cancer Research Program, IMIM-Hospital del Mar, Barcelona, Spain.
pubmed:publicationType	Journal Article, In Vitro, Research Support, Non-U.S. Gov't